Identification of a new quantitative trait locus on Chromosome 7 controlling disease severity of collagen-induced arthritis in rats

Svetlana V. Dracheva, Elaine F. Remmers, Pércio S. Gulko, Yutaka Kawahito, Ryan E. Longman, Van R. Reese, Grant W. Cannon, Marie M. Griffiths, Ronald L. Wilder

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Autoimmune diseases, such as rheumatoid arthritis, Crohn's disease, and multiple sclerosis, are regulated by multiple genes. Major histocompatibility complex (MHC) genes have the strongest effects, but non-MHC genes also contribute to disease susceptibility/severity. In this paper, we describe a new non-MHC quantitative trait locus, Cia8, on rat Chromosome (Chr) 7 that controls collagen-induced arthritis severity in F2 progeny of DA and F314 inbred rats, and present an updated localization of Cia4 on the same chromosome. We also describe the location of mouse and human genes, orthologous to the genes in the genomic intervals containing Cia4 and Cia8, and provide evidence that the segment of rat Chr 7 containing Cia4 and Cia8 is homologous to segments of mouse Chr 10 and 15 and human Chr 8, 12, and 19.

Original languageEnglish
Pages (from-to)787-791
Number of pages5
JournalImmunogenetics
Volume49
Issue number9
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Comparative maps
  • Inbred rats
  • Linkage mapping
  • Quantitative trait locus
  • Rheumatoid arthritis

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