Identification and Utilization of Donor and Recipient Genetic Variants to Predict Survival After HCT: Are We Ready for Primetime?

Lara E. Sucheston-Campbell, Alyssa Clay, Philip L. McCarthy, Qianqian Zhu, Leah Preus, Marcelo Pasquini, Kenan Onel, Theresa Hahn

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Overall survival following hematopoietic cell transplantation (HCT) has improved over the past two decades through better patient selection and advances in HLA typing, supportive care, and infection prophylaxis. Nonetheless, mortality rates are still unsatisfactory and transplant-related mortality remains a major cause of death after unrelated allogeneic HCT. Since there are no known pre-HCT, non-HLA biologic predictors of survival following transplant, for over a decade, scientists have been investigating the role of non-HLA germline genetic variation in survival and treatment-related mortality after HCT. Variation in single nucleotide polymorphisms (SNPs) has the potential to impact chemotherapy, radiation, and immune responses, leading to different post-HCT survival outcomes. In this paper, we address the current knowledge of the contribution of genetic variation to survival following HCT and discuss study design and methodology for investigating HCT survival on a genomic scale.

Original languageEnglish
Pages (from-to)45-58
Number of pages14
JournalCurrent Hematologic Malignancy Reports
Volume10
Issue number1
DOIs
StatePublished - 7 Mar 2015
Externally publishedYes

Keywords

  • HLA typing
  • Hematopoietic cell transplantation (HCT)
  • Infection prophylaxis
  • Non-HLA biologic predictors
  • SNPs

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