Hypoxia-Inducible Factor-1α: The Master Regulator of Endothelial Cell Senescence in Vascular Aging

Matilde Alique, Elsa Sánchez-López, Guillermo Bodega, Chiara Giannarelli, Julia Carracedo, Rafael Ramírez

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Aging is one of the hottest topics in biomedical research. Advances in research and medicine have helped to preserve human health, leading to an extension of life expectancy. However, the extension of life is an irreversible process that is accompanied by the development of aging-related conditions such as weakness, slower metabolism, and stiffness of vessels. It also debated that aging can be considered an actual disease with aging-derived comorbidities, including cancer or cardiovascular disease. Currently, cardiovascular disorders, including atherosclerosis, are considered as premature aging and represent the first causes of death in developed countries, accounting for 31% of annual deaths globally. Emerging evidence has identified hypoxia-inducible factor-1α as a critical transcription factor with an essential role in aging-related pathology, in particular, regulating cellular senescence associated with cardiovascular aging. In this review, we will focus on the regulation of senescence mediated by hypoxia-inducible factor-1α in age-related pathologies, with particular emphasis on the crosstalk between endothelial and vascular cells in age-associated atherosclerotic lesions. More specifically, we will focus on the characteristics and mechanisms by which cells within the vascular wall, including endothelial and vascular cells, achieve a senescent phenotype.

Original languageEnglish
Article number2980
JournalCells
Volume9
Issue number1
DOIs
StatePublished - 13 Jan 2020

Keywords

  • atherosclerosis
  • endothelial cells
  • extracellular vesicles
  • hypoxia-inducible factor-1α (HIF1α)
  • senescent cells
  • vascular aging
  • vascular smooth muscle cells

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