Hypotony in patients with uveitis: The Multicenter Uveitis Steroid Treatment (MUST) trial

H. Nida Sen, Lea T. Drye, Debra A. Goldstein, Theresa A. Larson, Pauline T. Merrill, Peter R. Pavan, John D. Sheppard, Alyce Burke, Sunil K. Srivastava, Douglas A. Jabs

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39 Scopus citations


Purpose: To assess the prevalence of hypotony in patients with severe forms of uveitis. Methods: The Multicenter Uveitis Steroid Treatment (MUST) Trial, a randomized study, enrolled 255 patients. Patients with hypotony at the baseline visit were identified. Results: Twenty (8.3%) of 240 patients with sufficient data had hypotony. Hypotony was more common in patients with uveitis ≥5 years duration (odds ratio [OR]=5.0; p <.01), and in eyes with a history of ocular surgery (vitrectomy vs. none, OR=3.1; p=.03). Hypotony was less in patients with older age of uveitis onset (>51 years vs. <51 years, OR=0.1; p=.02), in Caucasian patients (OR=0.1; p <.01) compared to African American patients. Hypotonous eyes were more likely to have visual impairment (OR=22.9; p <.01). Conclusions: Hypotony is an important complication of uveitis and more commonly affects African-American patients, those with uveitis onset at a younger age, and those with longer disease duration. It is associated with visual impairment.

Original languageEnglish
Pages (from-to)104-112
Number of pages9
JournalOcular Immunology and Inflammation
Issue number2
StatePublished - Apr 2012


  • Hypotony
  • Multicenter uveitis steroid treatment trial
  • Uveitis
  • Visual impairment
  • Visual loss


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