Hypothalamic self-stimulation differs as a function of anodal locus

Richard J. Bodnar; Solomon S. Steiner; Martin Brutus; Paula M. Ippolito; Steven J. Ellman

doi:10.3758/BF03326690

Hypothalamic self-stimulation differs as a function of anodal locus

Richard J. Bodnar
, Solomon S. Steiner
, Martin Brutus
, Paula M. Ippolito
, Steven J. Ellman

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Recent reports have questioned the exclusive role of cathodal influences in the mediation of intracranial self-stimulation (ICSS) behavior. The present study examined whether variation of anodal locus affected rat hypothalamic ICSS behavior. The temporal distance (C-C interval) between succeeding monophasic pulse pairs was held constant, while the temporal distance (C-T interval) between the two first and second pulses was systematically varied in each of two anodal conditions: (1) one pole of a bipolar electrode served as cathode and the other as anode (bipolar condition), and (2) one pole of a bipolar electrode served as cathode and a cortical screw served as anode (monopolar condition). The monopolar condition produced significantly higher ICSS response rates than the bipolar condition at short (0.5–1.0 msec) C-T intervals. These data suggest that anodal placement can influence ICSS responsivity, possibly through physiological mechanisms such as size of the stimulation field or anodal hyperpolarization.

Original language	English
Pages (from-to)	48-52
Number of pages	5
Journal	Physiological Psychology
Volume	6
Issue number	1
DOIs	https://doi.org/10.3758/BF03326690
State	Published - Mar 1978
Externally published	Yes

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title = "Hypothalamic self-stimulation differs as a function of anodal locus",

abstract = "Recent reports have questioned the exclusive role of cathodal influences in the mediation of intracranial self-stimulation (ICSS) behavior. The present study examined whether variation of anodal locus affected rat hypothalamic ICSS behavior. The temporal distance (C-C interval) between succeeding monophasic pulse pairs was held constant, while the temporal distance (C-T interval) between the two first and second pulses was systematically varied in each of two anodal conditions: (1) one pole of a bipolar electrode served as cathode and the other as anode (bipolar condition), and (2) one pole of a bipolar electrode served as cathode and a cortical screw served as anode (monopolar condition). The monopolar condition produced significantly higher ICSS response rates than the bipolar condition at short (0.5–1.0 msec) C-T intervals. These data suggest that anodal placement can influence ICSS responsivity, possibly through physiological mechanisms such as size of the stimulation field or anodal hyperpolarization.",

author = "Bodnar, \{Richard J.\} and Steiner, \{Solomon S.\} and Martin Brutus and Ippolito, \{Paula M.\} and Ellman, \{Steven J.\}",

year = "1978",

month = mar,

doi = "10.3758/BF03326690",

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T1 - Hypothalamic self-stimulation differs as a function of anodal locus

AU - Bodnar, Richard J.

AU - Steiner, Solomon S.

AU - Brutus, Martin

AU - Ippolito, Paula M.

AU - Ellman, Steven J.

PY - 1978/3

Y1 - 1978/3

N2 - Recent reports have questioned the exclusive role of cathodal influences in the mediation of intracranial self-stimulation (ICSS) behavior. The present study examined whether variation of anodal locus affected rat hypothalamic ICSS behavior. The temporal distance (C-C interval) between succeeding monophasic pulse pairs was held constant, while the temporal distance (C-T interval) between the two first and second pulses was systematically varied in each of two anodal conditions: (1) one pole of a bipolar electrode served as cathode and the other as anode (bipolar condition), and (2) one pole of a bipolar electrode served as cathode and a cortical screw served as anode (monopolar condition). The monopolar condition produced significantly higher ICSS response rates than the bipolar condition at short (0.5–1.0 msec) C-T intervals. These data suggest that anodal placement can influence ICSS responsivity, possibly through physiological mechanisms such as size of the stimulation field or anodal hyperpolarization.

AB - Recent reports have questioned the exclusive role of cathodal influences in the mediation of intracranial self-stimulation (ICSS) behavior. The present study examined whether variation of anodal locus affected rat hypothalamic ICSS behavior. The temporal distance (C-C interval) between succeeding monophasic pulse pairs was held constant, while the temporal distance (C-T interval) between the two first and second pulses was systematically varied in each of two anodal conditions: (1) one pole of a bipolar electrode served as cathode and the other as anode (bipolar condition), and (2) one pole of a bipolar electrode served as cathode and a cortical screw served as anode (monopolar condition). The monopolar condition produced significantly higher ICSS response rates than the bipolar condition at short (0.5–1.0 msec) C-T intervals. These data suggest that anodal placement can influence ICSS responsivity, possibly through physiological mechanisms such as size of the stimulation field or anodal hyperpolarization.

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JO - Physiological Psychology

JF - Physiological Psychology

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ER -

Hypothalamic self-stimulation differs as a function of anodal locus

Abstract

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