Hypothalamic-pituitary-adrenal alterations in PTSD: Are they relevant to understanding cortisol alterations in cancer?

Rachel Yehuda

doi:10.1016/s0889-1591(02)00070-3

Hypothalamic-pituitary-adrenal alterations in PTSD: Are they relevant to understanding cortisol alterations in cancer?

Rachel Yehuda

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Recent studies of hypothalamic-pituitary-adrenal axis alterations in PTSD have demonstrated a specific type of hyperresponsivity of this stress hormonal system characterized by a greater negative feedback inhibition of cortisol, which may paradoxically serve to lower cortisol levels. The occurrence of cancer has been recently described by many investigators as an event that fulfills the DSM-IV criteria for a "traumatic event" that has been demonstrated in some cases to be linked with the subsequent development of PTSD. This review considers the extent to which neuroendocrine alterations observed in PTSD may be useful in understanding cortisol alterations involved in cancer.

Original language	English
Pages (from-to)	73-83
Number of pages	11
Journal	Brain, Behavior, and Immunity
Volume	17
Issue number	1 SUPPL.
DOIs	https://doi.org/10.1016/s0889-1591(02)00070-3
State	Published - Feb 2003

Keywords

Cancer
Cortisol
Early trauma
Negative feedback inhibition
Posttraumatic stress disorder

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10.1016/s0889-1591(02)00070-3

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title = "Hypothalamic-pituitary-adrenal alterations in PTSD: Are they relevant to understanding cortisol alterations in cancer?",

abstract = "Recent studies of hypothalamic-pituitary-adrenal axis alterations in PTSD have demonstrated a specific type of hyperresponsivity of this stress hormonal system characterized by a greater negative feedback inhibition of cortisol, which may paradoxically serve to lower cortisol levels. The occurrence of cancer has been recently described by many investigators as an event that fulfills the DSM-IV criteria for a {"}traumatic event{"} that has been demonstrated in some cases to be linked with the subsequent development of PTSD. This review considers the extent to which neuroendocrine alterations observed in PTSD may be useful in understanding cortisol alterations involved in cancer.",

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author = "Rachel Yehuda",

note = "Funding Information: This work was supported by MH 49555, MH 55-7531, and MERIT review funding.",

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AB - Recent studies of hypothalamic-pituitary-adrenal axis alterations in PTSD have demonstrated a specific type of hyperresponsivity of this stress hormonal system characterized by a greater negative feedback inhibition of cortisol, which may paradoxically serve to lower cortisol levels. The occurrence of cancer has been recently described by many investigators as an event that fulfills the DSM-IV criteria for a "traumatic event" that has been demonstrated in some cases to be linked with the subsequent development of PTSD. This review considers the extent to which neuroendocrine alterations observed in PTSD may be useful in understanding cortisol alterations involved in cancer.

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KW - Cortisol

KW - Early trauma

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ER -

Hypothalamic-pituitary-adrenal alterations in PTSD: Are they relevant to understanding cortisol alterations in cancer?

Abstract

Keywords

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