Abstract
This study investigated the neural correlates of hypophonia in individuals with Idiopathic Parkinson's disease (IPD) before and after the Lee Silverman Voice Treatment (LSVT), using 15O-H2O Positron Emission Tomography (PET). Regional cerebral blood flow (rCBF) changes associated with overt speech-motor tasks relative to the resting state were measured in the IPD subjects before and after therapy, and in a group of healthy controls. Before LSVT, patients had strong speechrelated activations in motor and premotor cortex, supplementary motor cortex and inferior lateral premotor cortex which were significantly reduced post-LSVT. In addition, significant right-sided activations were present in anterior insular cortex, caudate head, putamen, and dorsolateral prefrontal cortex following LSVT. Finally, the LSVT-induced neural changes were not present with transient experimentercued increases of loudness in LSVT-untreated patients. This treatment-dependant functional reorganization suggests a shift from an abnormally effortful to a more automatic implementation of speech-motor actions.
| Original language | English |
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| Pages | 2477-2480 |
| Number of pages | 4 |
| State | Published - 2002 |
| Externally published | Yes |
| Event | 7th International Conference on Spoken Language Processing, ICSLP 2002 - Denver, United States Duration: 16 Sep 2002 → 20 Sep 2002 |
Conference
| Conference | 7th International Conference on Spoken Language Processing, ICSLP 2002 |
|---|---|
| Country/Territory | United States |
| City | Denver |
| Period | 16/09/02 → 20/09/02 |