TY - JOUR
T1 - Hypopharyngeal cancer
T2 - A state of the art review
AU - Garneau, Jonathan C.
AU - Bakst, Richard L.
AU - Miles, Brett A.
N1 - Publisher Copyright:
© 2018
PY - 2018/11
Y1 - 2018/11
N2 - Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30–35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. In this article, we set out to discuss a comprehensive overview of the current management principles, recent literature and evidence based therapeutic options surrounding treatment for hypopharyngeal squamous cell carcinoma, with a special focus on the evolution of an organ sparing paradigm.
AB - Cancer of the hypopharynx is relatively rare and accounts for roughly 3% of all head and neck cancers. Unfortunately, hypopharyngeal carcinoma has one of the worst prognosis of all head and neck cancers with a reported 5-year overall survival rate of approximately 30–35%. Toxicity related to therapy, and the need for surgical salvage continue to dominate the landscape in this disease. In this article, we set out to discuss a comprehensive overview of the current management principles, recent literature and evidence based therapeutic options surrounding treatment for hypopharyngeal squamous cell carcinoma, with a special focus on the evolution of an organ sparing paradigm.
KW - Head and neck squamous cell carcinoma
KW - Hypopharyngeal cancer
KW - Hypopharyngeal carcinoma
KW - Laryngeal preservation
UR - http://www.scopus.com/inward/record.url?scp=85054158917&partnerID=8YFLogxK
U2 - 10.1016/j.oraloncology.2018.09.025
DO - 10.1016/j.oraloncology.2018.09.025
M3 - Article
C2 - 30409307
AN - SCOPUS:85054158917
SN - 1368-8375
VL - 86
SP - 244
EP - 250
JO - Oral Oncology
JF - Oral Oncology
ER -