Hypocretin and brain reward function

Benjamin Boutrel, Paul J. Kenny, Athina Markou, George F. Koob

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Hypocretin-containing neurons arise exclusively in the lateral hypothalamus (LH) and project widely throughout the brain,1 with a dense innervation of anatomical sites involved in regulating arousal, motivation, and stress states.2 Their interaction with autonomic, neuroendocrine and neuroregulatory systems2-12 strongly suggests they act as neuromodulators in a wide variety of neural circuits. The hypocretins (Hcrt-1 and Hcrt-2), also known as orexins, have been implicated in the modulation of noradrenergic,6,13-15 cholinergic,16 serotonergic,17,18 histaminergic19 and dopaminergic systems,20,21 and in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis,22-24 possibly via the release of neuropeptide Y.25 Hence, the hypocretin/orexin system could constitute a sensitive key relay for mediating stress behaviors.7,26.

Original languageEnglish
Title of host publicationHypocretins
Subtitle of host publicationIntegrators of Physiological Functions
PublisherSpringer US
Pages317-326
Number of pages10
ISBN (Electronic)9780387254463
ISBN (Print)038725000X, 9780387250007
DOIs
StatePublished - 2005
Externally publishedYes

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