Hypocretin and brain reward function

Benjamin Boutrel, Paul J. Kenny, Athina Markou, George F. Koob

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Hypocretin-containing neurons arise exclusively in the lateral hypothalamus (LH) and project widely throughout the brain,1 with a dense innervation of anatomical sites involved in regulating arousal, motivation, and stress states.2 Their interaction with autonomic, neuroendocrine and neuroregulatory systems2-12 strongly suggests they act as neuromodulators in a wide variety of neural circuits. The hypocretins (Hcrt-1 and Hcrt-2), also known as orexins, have been implicated in the modulation of noradrenergic,6,13-15 cholinergic,16 serotonergic,17,18 histaminergic19 and dopaminergic systems,20,21 and in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis,22-24 possibly via the release of neuropeptide Y.25 Hence, the hypocretin/orexin system could constitute a sensitive key relay for mediating stress behaviors.7,26.

Original languageEnglish
Title of host publicationHypocretins
Subtitle of host publicationIntegrators of Physiological Functions
PublisherSpringer US
Number of pages10
ISBN (Electronic)9780387254463
ISBN (Print)038725000X, 9780387250007
StatePublished - 2005
Externally publishedYes


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