Hypocretin-containing neurons arise exclusively in the lateral hypothalamus (LH) and project widely throughout the brain,1 with a dense innervation of anatomical sites involved in regulating arousal, motivation, and stress states.2 Their interaction with autonomic, neuroendocrine and neuroregulatory systems2-12 strongly suggests they act as neuromodulators in a wide variety of neural circuits. The hypocretins (Hcrt-1 and Hcrt-2), also known as orexins, have been implicated in the modulation of noradrenergic,6,13-15 cholinergic,16 serotonergic,17,18 histaminergic19 and dopaminergic systems,20,21 and in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis,22-24 possibly via the release of neuropeptide Y.25 Hence, the hypocretin/orexin system could constitute a sensitive key relay for mediating stress behaviors.7,26.
|Title of host publication||Hypocretins|
|Subtitle of host publication||Integrators of Physiological Functions|
|Number of pages||10|
|ISBN (Print)||038725000X, 9780387250007|
|State||Published - 2005|