TY - JOUR
T1 - Hypoallergenicity and efficacy of an amino acid-based formula in children with cow's milk and multiple food hypersensitivities
AU - Sicherer, Scott H.
AU - Noone, Sally A.
AU - Koerner, Celide Barnes
AU - Christie, Lynn
AU - Burks, A. Wesley
AU - Sampson, Hugh A.
N1 - Funding Information:
Supported by Ross Products Division, Abbott Laboratories, Columbus, Ohio.
PY - 2001
Y1 - 2001
N2 - Objective: To determine the hypoallergenicity and efficacy of a pediatric amino acid-based formula (AAF), EleCare, for children with cow's milk allergy (CMA) and multiple food allergies (MFA). Study design: Hypoallergenicity was determined by performing blinded oral food challenges in 31 consecutive children with documented CMA. Growth, tolerance, and biochemical response were evaluated during a nonrandomized feeding study with each child serving as his or her own control. Results: Thirty-one children (median age, 23.3 months; range, 6 months to 17.5 years) were recruited; 29 had MFA, 17 had acute reactions and cow's milk-specific IgE antibody, and 14 had allergic eosinophilic gastroenteritis. At study entry, 23 were receiving another AAF; 13 had not tolerated extensively hydrolyzed formula. Eighteen subjects with allergic eosinophilic gastroenteritis and/or MFA were followed up while receiving AAF for a median of 21 months (range, 7 to 40 months), with biochemical analysis performed at 4 months. No statistically significant differences were observed in the change in weight or height National Center for Health Statistics z scores from entry; the percent of expected growth exceeded 90%. There was a small decline in percent eosinophils and increase in hemoglobin, hematocrit, and serum ferritin level (P < .05). Except for small increases in plasma leucine and saline levels (P ≤ .006), the remaining biochemical markers were unchanged. Conclusions: The AAF was hypoallergenic and effective in maintaining normal growth for children with CMA and MFA.
AB - Objective: To determine the hypoallergenicity and efficacy of a pediatric amino acid-based formula (AAF), EleCare, for children with cow's milk allergy (CMA) and multiple food allergies (MFA). Study design: Hypoallergenicity was determined by performing blinded oral food challenges in 31 consecutive children with documented CMA. Growth, tolerance, and biochemical response were evaluated during a nonrandomized feeding study with each child serving as his or her own control. Results: Thirty-one children (median age, 23.3 months; range, 6 months to 17.5 years) were recruited; 29 had MFA, 17 had acute reactions and cow's milk-specific IgE antibody, and 14 had allergic eosinophilic gastroenteritis. At study entry, 23 were receiving another AAF; 13 had not tolerated extensively hydrolyzed formula. Eighteen subjects with allergic eosinophilic gastroenteritis and/or MFA were followed up while receiving AAF for a median of 21 months (range, 7 to 40 months), with biochemical analysis performed at 4 months. No statistically significant differences were observed in the change in weight or height National Center for Health Statistics z scores from entry; the percent of expected growth exceeded 90%. There was a small decline in percent eosinophils and increase in hemoglobin, hematocrit, and serum ferritin level (P < .05). Except for small increases in plasma leucine and saline levels (P ≤ .006), the remaining biochemical markers were unchanged. Conclusions: The AAF was hypoallergenic and effective in maintaining normal growth for children with CMA and MFA.
UR - http://www.scopus.com/inward/record.url?scp=0035002481&partnerID=8YFLogxK
U2 - 10.1067/mpd.2001.113007
DO - 10.1067/mpd.2001.113007
M3 - Article
C2 - 11343044
AN - SCOPUS:0035002481
SN - 0022-3476
VL - 138
SP - 688
EP - 693
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -