Hyperthermia treatment advances for brain tumors

Georgios P. Skandalakis, Daniel R. Rivera, Caroline D. Rizea, Alexandros Bouras, Joe Gerald Jesu Raj, Dominique Bozec, Constantinos G. Hadjipanayis

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deep-seated tumors in the brain. Magnetic hyperthermia therapy (MHT), which relies on the use of magnetic nanoparticles (MNPs) and alternating magnetic fields (AMFs), is a new quite promising HT treatment approach for brain tumors. Initial MHT clinical studies in combination with fractionated radiation therapy (RT) in patients have been completed in Europe with encouraging results. Another combination treatment with HT that warrants further investigation is immunotherapy. HT approaches for brain tumors will continue to a play an important role in neuro-oncology.

Original languageEnglish
Pages (from-to)3-19
Number of pages17
JournalInternational Journal of Hyperthermia
Issue number2
StatePublished - 31 Jul 2020


  • Brain tumor
  • hyperthermia therapy
  • laser interstitial thermal therapy
  • magnetic hyperthermia therapy
  • photothermal therapy


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