Hypertension urgencies in the SPYRAL HTN-OFF MED Pivotal trial

Michael A. Weber, Roland E. Schmieder, David E. Kandzari, Raymond R. Townsend, Felix Mahfoud, Konstantinos Tsioufis, Kazuomi Kario, Stuart Pocock, Fotis Tatakis, Sebastian Ewen, James W. Choi, Cara East, David P. Lee, Adrian Ma, Debbie L. Cohen, Robert Wilensky, Chandan M. Devireddy, Janice P. Lea, Axel Schmid, Martin FahyMichael Böhm

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The SPYRAL HTN-OFF MED Pivotal trial (https://clinicaltrials.gov/ct2/show/NCT02439749) demonstrated significant reductions in blood pressure (BP) after renal denervation (RDN) compared to sham control in the absence of anti-hypertensive medications. Prior to the 3-month primary endpoint, medications were immediately reinstated for patients who met escape criteria defined as office systolic BP (SBP) ≥ 180 mmHg or other safety concerns. Our objective was to compare the rate of hypertensive urgencies in RDN vs. sham control patients. Patients were enrolled with office SBP ≥ 150 and < 180 mmHg, office diastolic BP (DBP) ≥ 90 mmHg and mean 24 h SBP ≥ 140 and < 170 mmHg. Patients had been required to discontinue any anti-hypertensive medications and were randomized 1:1 to RDN or sham control. In this post-hoc analysis, cumulative incidence curves with Kaplan–Meier estimates of rate of patients meeting escape criteria were generated for RDN and sham control patients. There were 16 RDN (9.6%) and 28 sham control patients (17.0%) who met escape criteria between baseline and 3 months. There was a significantly higher rate of sham control patients meeting escape criteria compared to RDN for all escape patients (p = 0.032), as well as for patients with a hypertensive urgency with office SBP ≥ 180 mmHg (p = 0.046). Rate of escape was similar between RDN and sham control for patients without a measured BP exceeding 180 mmHg (p = 0.32). In the SPYRAL HTN-OFF MED Pivotal trial, RDN patients were less likely to experience hypertensive urgencies that required immediate use of anti-hypertensive medications compared to sham control. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)1269-1275
Number of pages7
JournalClinical Research in Cardiology
Volume111
Issue number11
DOIs
StatePublished - Nov 2022
Externally publishedYes

Keywords

  • Blood pressure
  • Hypertension
  • Hypertensive urgency
  • Renal denervation

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