Hypertension and childhood stroke

Juan C. Kupferman, Marc B. Lande, Stella Stabouli, Dimitrios I. Zafeiriou, Steven G. Pavlakis

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Cerebrovascular disease (stroke) is one of the ten leading causes of death in children and adolescents. Multiple etiologies, from arteriopathies to prothrombic states, can cause stroke in youth. In adult stroke, hypertension has been shown to be the single most important modifiable risk factor. Although hypertension has not been strongly identified as a risk factor in childhood stroke to date, there is preliminary evidence that suggests that hypertension may also be associated with stroke in children. In this review, we summarize the literature that may link hypertension to stroke in the young. We have identified a series of barriers and limitations in the fields of pediatric hypertension and pediatric neurology that might explain why hypertension has been overlooked in childhood stroke. We suggest that hypertension may be a relevant risk factor that, alone or in combination with other multiple factors, contributes to the development of stroke in children. Currently, there are no consensus guidelines for the management of post-stroke hypertension in children. Thus, we recommend that blood pressure be assessed carefully in every child presenting with acute stroke in order to better understand the effects of hypertension in the development and the outcome of childhood stroke. We suggest a treatment algorithm to help practitioners manage hypertension after a stroke.

Original languageEnglish
Pages (from-to)809-823
Number of pages15
JournalPediatric Nephrology
Issue number4
StatePublished - Apr 2021
Externally publishedYes


  • Cerebrovascular disease
  • Children
  • Elevated blood pressure
  • Hemorrhagic
  • Ischemic
  • Pediatric


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