Hypersecretion of Gastrin Associated with the Short Bowel Syndrome

Eugene Straus, Charles D. Gerson, Rosalyn S. Yalow

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


Marked hypergastrinemia characterized by high fasting levels and a prompt sharp response to a standard test meal was observed in a group of 4 patients with short bowel syndrome, but not in a patient with jejunoileal bypass. In keeping with the findings in other gastrin hypersecreters, the predominant form of circulating gastrin in the patients with short bowel syndrome was big gastrin. The possibility that hypergastrinemia might result from the absence of a factor in the distal small intestine that inhibits gastrin release is considered.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
Issue number2
StatePublished - 1974
Externally publishedYes


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