Hyperprolactinemia fails to increase striatal dopamine receptors in male and female C57BL/6J mice

David G. Morgan, Charles V. Mobbs, Christopher P. Anderson, Yogi N. Sinha, Caleb E. Finch

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mice were administered prolactin by either homotypic anterior pituitary grafts (4 weeks) or subcutaneous osmotic pumps containing ovine prolactin (1 week). The pituitary grafts produced considerably greater elevations of circulating prolactin than the osmotic pumps. In neither case was any change detected in striatal [3H]spiperone binding to dopamine receptors. These results are discussed in the context of contradictory obtained with rats.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalEuropean Journal of Pharmacology
Volume107
Issue number1
DOIs
StatePublished - 15 Dec 1984
Externally publishedYes

Keywords

  • Dopamine receptors
  • Pituitary graft
  • Prolactin
  • Striatum

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