TY - JOUR
T1 - Hyperinsulinemic hypoglycemia of infancy
T2 - Recent insights into ATP- sensitive potassium channels, sulfonylurea receptors, molecular mechanisms, and treatment
AU - Sperling, M. A.
AU - Menon, R. K.
PY - 1999
Y1 - 1999
N2 - Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), previously termed 'nesidioblastosis', is an important cause of hypoglycemia in infancy and childhood. Recent studies have defined this syndrome at the molecular, genetic, and clinical level. This article reviews the genetic and molecular basis of these entities, describes their clinical manifestations, and discusses the rationales for available therapeutic options.
AB - Persistent hyperinsulinemic hypoglycemia of infancy (PHHI), previously termed 'nesidioblastosis', is an important cause of hypoglycemia in infancy and childhood. Recent studies have defined this syndrome at the molecular, genetic, and clinical level. This article reviews the genetic and molecular basis of these entities, describes their clinical manifestations, and discusses the rationales for available therapeutic options.
UR - http://www.scopus.com/inward/record.url?scp=0032761784&partnerID=8YFLogxK
U2 - 10.1016/S0889-8529(05)70097-9
DO - 10.1016/S0889-8529(05)70097-9
M3 - Article
C2 - 10609115
AN - SCOPUS:0032761784
SN - 0889-8529
VL - 28
SP - 695
EP - 708
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 4
ER -