Hyperbaric oxygenation: Oxygen exchange in an acutely ischemic vascular bed

Michael C.H. Wang, Theobald Reich, William S. Lesko, Julius H. Jacobson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

1. 1. Occlusion of the infrarenal aorta while breathing air and 100 percent oxygen at 1 ATA resulted in a marked drop in femoral venous pO2. Breathing 100 percent oxygen at 3 ATA under the same circumstances elevated the femoral venous pO2 to a level higher than that measured before aortic occlusion while breathing air at 1 ATA. 2. 2. Excess lactate production in femoral venous blood during aortic occlusion for one hour at normal atmospheric pressure did not occur during aortic occlusion while breathing 100 percent oxygen at 3 ATA. 3. 3. Release of abdominal aortic occlusion after one hour resulted in hypotension in animals breathing air at normal atmospheric pressure. Breathing 100 percent oxygen at 3 ATA prevented hypotension. 4. 4. These observations are interpreted as showing that hyperbaric oxygenation provided protection against hypoxia in the canine hind limbs following abdominal aortic occlusion. Similar observations have been recorded in human patients during abdominal aortic aneurysm resections performed under hyperbaric oxygenation.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalSurgery
Volume59
Issue number1
StatePublished - Jan 1966
Externally publishedYes

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