Hyodeoxycholic acid: A new approach to gallstone prevention

Charles K. McSherry; Erwin H. Mosbach; Bertram I. Cohen; Mizuho Une; Richard J. Stenger; Anil K. Singhal

doi:10.1016/S0002-9610(85)80021-0

Hyodeoxycholic acid: A new approach to gallstone prevention

Charles K. McSherry, Erwin H. Mosbach, Bertram I. Cohen, Mizuho Une, Richard J. Stenger, Anil K. Singhal

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Hyodeoxycholic acid and its isomer, 6β-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6β-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

Original language	English
Pages (from-to)	126-132
Number of pages	7
Journal	American Journal of Surgery
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/S0002-9610(85)80021-0
State	Published - Jan 1985

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title = "Hyodeoxycholic acid: A new approach to gallstone prevention",

abstract = "Hyodeoxycholic acid and its isomer, 6β-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6β-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.",

author = "McSherry, {Charles K.} and Mosbach, {Erwin H.} and Cohen, {Bertram I.} and Mizuho Une and Stenger, {Richard J.} and Singhal, {Anil K.}",

note = "Funding Information: Fnom the Departmentso f Surgerya nd Pathology,B eth Israel Medical Center and The Mount Sinai School of Medicine of the City Universityo f New york, New York, New York..Th|sw ork was supportedi n part by United States Public Health Service Grant HL 24061 from the National Heart, Lung and Blood Institute and Grant CA 25673 from the National Cancer Institute, Bethesda, Maryland. : Requests for reprints Should be addressed to Charles K. McSherry, MD, Department of Surgery. Beth Israel Medical Center, 10 Nathan D. Perlman Place, New york, New York 10003.",

year = "1985",

month = jan,

doi = "10.1016/S0002-9610(85)80021-0",

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T1 - Hyodeoxycholic acid

T2 - A new approach to gallstone prevention

AU - McSherry, Charles K.

AU - Mosbach, Erwin H.

AU - Cohen, Bertram I.

AU - Une, Mizuho

AU - Stenger, Richard J.

AU - Singhal, Anil K.

N1 - Funding Information: Fnom the Departmentso f Surgerya nd Pathology,B eth Israel Medical Center and The Mount Sinai School of Medicine of the City Universityo f New york, New York, New York..Th|sw ork was supportedi n part by United States Public Health Service Grant HL 24061 from the National Heart, Lung and Blood Institute and Grant CA 25673 from the National Cancer Institute, Bethesda, Maryland. : Requests for reprints Should be addressed to Charles K. McSherry, MD, Department of Surgery. Beth Israel Medical Center, 10 Nathan D. Perlman Place, New york, New York 10003.

PY - 1985/1

Y1 - 1985/1

N2 - Hyodeoxycholic acid and its isomer, 6β-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6β-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

AB - Hyodeoxycholic acid and its isomer, 6β-hyodeoxycholic acid, when added to a lithogenic diet prevented the formation of cholesterol gallstones and crystals in prairie dogs. This beneficial effect occurred in the presence of bile supersaturated with cholesterol. Hyodeoxycholic acid abolished the feedback inhibition of hepatic hydroxymethylglutaryl coenzyme A reductase activity, the rate-limiting enzyme of cholesterol synthesis, and prevented elevations in serum and liver cholesterol observed in animals fed a 0.4 percent cholesterol diet. The gallbladder bile of the animals fed hyodeoxycholic acid and 6β-hyodeoxycholic acid contained abundant liquid crystals. This suggests that these bile acids prevented the transition of cholesterol from its liquid crystalline phase to solid crystals and stones.

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JO - American Journal of Surgery

JF - American Journal of Surgery

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ER -

Hyodeoxycholic acid: A new approach to gallstone prevention

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