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Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity

  • Lewis D. Pennington
  • , Douglas A. Whittington
  • , Michael D. Bartberger
  • , Steven R. Jordan
  • , Holger Monenschein
  • , Thomas T. Nguyen
  • , Bryant H. Yang
  • , Qiufen M. Xue
  • , Filisaty Vounatsos
  • , Robert C. Wahl
  • , Kui Chen
  • , Stephen Wood
  • , Martin Citron
  • , Vinod F. Patel
  • , Stephen A. Hitchcock
  • , Wenge Zhong

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science

Chemistry