Hydrolysates of egg white proteins modulate T- and B-cell responses in mitogen-stimulated murine cells

Daniel Lozano-Ojalvo, Elena Molina, Rosina López-Fandiño

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

This work assessed the effects of hydrolysates of ovalbumin (OVA), lysozyme (LYS), ovomucoid (OM) and whole egg white (EW) on cytokine secretion, antibody production, oxidative stress and proliferation of murine spleen and mesenteric lymph node cells stimulated with T- (concanavalin A-ConA) or B-cell mitogens (lipopolysaccharide-LPS). The hydrolysates of OVA, LYS and EW with alcalase reduced ConA-stimulated lymphocyte proliferation and production of Th2-biased cytokines, such as IL-13 and IL-10, and decreased the secretion of the Th1 cytokine TNF-α. In addition, these hydrolysates considerably inhibited IgG1-class switching induced by LPS and counteracted the release of reactive oxygen species. EW peptides modulated the immune responses of murine cells to mitogen stimuli, revealing potential activities that could be used for different purposes as Th1- or Th2-skewing mediators.

Original languageEnglish
Pages (from-to)1048-1056
Number of pages9
JournalFood and Function
Volume7
Issue number2
DOIs
StatePublished - Feb 2016
Externally publishedYes

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