'Hybrid resistance' against parental tumors: One or several genetic patterns?

George Klein, Gunnar O. Klein, Klas Kärre, Rolf Kiessling

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

A spectrum of lymphomas, sarcomas, and carcinomas were tested for F1 hybrid resistance after s.c. inoculation of small numbers of cells into syngeneic and F1 hybrid mice. Significant F1 resistance was demonstrated against all tumors tested except one. Backcross and/or congenic inoculation tests showed significant H-2 linkage of hybrid resistance against all lymphomas and leukemias tested. There was no linkage between H-2 and hybrid resistance within the more limited group of carcinomas and sarcomas. Different H-2-linked resistance genes were shown to act against different lymphomas, including some that were induced by the same agent. Some lymphomas induced by different agents in the same strain were also found to differ in their sensitivity to the same H-2 -linked resistance factor. These data suggest the existence of a polymorphic system, probably pseudoallelic, rather than simply allelic in nature.

Original languageEnglish
Pages (from-to)391-404
Number of pages14
JournalImmunogenetics
Volume7
Issue number1
DOIs
StatePublished - Dec 1978
Externally publishedYes

Fingerprint

Dive into the research topics of ''Hybrid resistance' against parental tumors: One or several genetic patterns?'. Together they form a unique fingerprint.

Cite this