Hyalocytes in proliferative vitreo-retinal diseases

Charlotte H. Jones, Wei Gui, Ricarda G. Schumann, Stefaniya K. Boneva, Clemens A.K. Lange, Koen A. van Overdam, Toco Y.P. Chui, Richard B. Rosen, Michael Engelbert, J. Sebag

Research output: Contribution to journalLetterpeer-review

2 Scopus citations


Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.

Original languageEnglish
Pages (from-to)263-280
Number of pages18
JournalExpert Review of Ophthalmology
Issue number4
StatePublished - 2022


  • Vitreous
  • anomalous PVD
  • hyalocytes
  • macular pucker
  • proliferative diabetic vitreo-retinopathy
  • proliferative vitreo-retinopathy
  • vitreoschisis


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