TY - JOUR
T1 - Hyalocytes in proliferative vitreo-retinal diseases
AU - Jones, Charlotte H.
AU - Gui, Wei
AU - Schumann, Ricarda G.
AU - Boneva, Stefaniya K.
AU - Lange, Clemens A.K.
AU - van Overdam, Koen A.
AU - Chui, Toco Y.P.
AU - Rosen, Richard B.
AU - Engelbert, Michael
AU - Sebag, J.
N1 - Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.
AB - Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.
KW - Vitreous
KW - anomalous PVD
KW - hyalocytes
KW - macular pucker
KW - proliferative diabetic vitreo-retinopathy
KW - proliferative vitreo-retinopathy
KW - vitreoschisis
UR - http://www.scopus.com/inward/record.url?scp=85137798010&partnerID=8YFLogxK
U2 - 10.1080/17469899.2022.2100764
DO - 10.1080/17469899.2022.2100764
M3 - Letter
AN - SCOPUS:85137798010
SN - 1746-9899
VL - 17
SP - 263
EP - 280
JO - Expert Review of Ophthalmology
JF - Expert Review of Ophthalmology
IS - 4
ER -