TY - JOUR
T1 - Hyalocytes in proliferative vitreo-retinal diseases
AU - Jones, Charlotte H.
AU - Gui, Wei
AU - Schumann, Ricarda G.
AU - Boneva, Stefaniya K.
AU - Lange, Clemens A.K.
AU - van Overdam, Koen A.
AU - Chui, Toco Y.P.
AU - Rosen, Richard B.
AU - Engelbert, Michael
AU - Sebag, J.
N1 - Funding Information:
This paper was funded by the VMR Research Foundation (J Sebag), Research to Prevent Blindness (TYP Chui and RB Rosen), the Marrus Family Foundation (TYP Chui and RB Rosen), the New York Eye and Ear Infirmary Foundation (TYP Chui and RB Rosen) National Institutes of Health (R01EY027301, R01HL159116; TYP Chui and RB Rosen), and the Ernst and Berta Grimmke Foundation (S K Boneva).
Publisher Copyright:
© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.
AB - Introduction: Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases. Areas covered: Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes. Expert opinion: Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely.
KW - Vitreous
KW - anomalous PVD
KW - hyalocytes
KW - macular pucker
KW - proliferative diabetic vitreo-retinopathy
KW - proliferative vitreo-retinopathy
KW - vitreoschisis
UR - http://www.scopus.com/inward/record.url?scp=85137798010&partnerID=8YFLogxK
U2 - 10.1080/17469899.2022.2100764
DO - 10.1080/17469899.2022.2100764
M3 - Letter
AN - SCOPUS:85137798010
SN - 1746-9899
VL - 17
SP - 263
EP - 280
JO - Expert Review of Ophthalmology
JF - Expert Review of Ophthalmology
IS - 4
ER -