TY - JOUR
T1 - Hyaline Membrane Disease
T2 - A Controlled Study of Inspiratory to Expiratory Ratio in Its Management by Ventilator
AU - Spahr, Robert C.
AU - Klein, Alan M.
AU - Brown, David R.
AU - Macdonald, Hugh M.
AU - Holzman, Ian R.
PY - 1980/4
Y1 - 1980/4
N2 - Sixty-nine neonates with severe hyaline membrane disease (HMD) were mechanically ventilated using either a 1:2 or a 2:1 inspiratory to expiratory (I/E) ratio. Survivors in the 2:1 group required a lower fraction of oxygen in the inspired air (FiO2) and lower end-expiratory pressure to achieve satisfactory oxygenation. During the first week of life, time of exposure to FiO2 > 0.60 while being mechanically ventilated was 29.7 ± 7.5 hours for the 1:2 group and 6.9 ± 2.7 hours for the 2:1 group, while time of exposure to endexpiratory pressure > 3 cm H2O was 49.4 ± 7.9 hours for the 1:2 group and 13.4 ± 7.4 hours for the 2:1 group. Mortality and the incidence of air leak, patent ductus arteriosus, intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, and pulmonary hemorrhage were not different for the two groups. Using an increased I/E ratio during the acute phase of HMD improved oxygenation but did not alter morbidity or mortality.
AB - Sixty-nine neonates with severe hyaline membrane disease (HMD) were mechanically ventilated using either a 1:2 or a 2:1 inspiratory to expiratory (I/E) ratio. Survivors in the 2:1 group required a lower fraction of oxygen in the inspired air (FiO2) and lower end-expiratory pressure to achieve satisfactory oxygenation. During the first week of life, time of exposure to FiO2 > 0.60 while being mechanically ventilated was 29.7 ± 7.5 hours for the 1:2 group and 6.9 ± 2.7 hours for the 2:1 group, while time of exposure to endexpiratory pressure > 3 cm H2O was 49.4 ± 7.9 hours for the 1:2 group and 13.4 ± 7.4 hours for the 2:1 group. Mortality and the incidence of air leak, patent ductus arteriosus, intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, and pulmonary hemorrhage were not different for the two groups. Using an increased I/E ratio during the acute phase of HMD improved oxygenation but did not alter morbidity or mortality.
UR - https://www.scopus.com/pages/publications/0018858738
U2 - 10.1001/archpedi.1980.04490010031011
DO - 10.1001/archpedi.1980.04490010031011
M3 - Article
C2 - 6768286
AN - SCOPUS:0018858738
SN - 0002-922X
VL - 134
SP - 373
EP - 376
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 4
ER -