Humoral Hypercalcemia of Cancer

Jeffrey S. Flier; Lisa H. Underhill; Arthur E. Broadus; Marguerite Mangin; Kyoji Ikeda; Karl L. Insogna; Eleanor C. Weir; William J. Burtis; Andrew F. Stewart

doi:10.1056/NEJM198809013190906

Humoral Hypercalcemia of Cancer

Jeffrey S. Flier, Lisa H. Underhill, Arthur E. Broadus, Marguerite Mangin, Kyoji Ikeda, Karl L. Insogna, Eleanor C. Weir, William J. Burtis, Andrew F. Stewart

Research output: Contribution to journal › Review article › peer-review

350 Scopus citations

Abstract

THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.¹ When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that the tumor was secreting parathyroid hormone or a peptide with similar actions. Interest in this syndrome has persisted, and has become particularly intense during the past decade. In the past six months, three groups have isolated and partially sequenced the amino terminus of a parathyroid hormone-like peptide obtained from four different tumors associated with humoral hypercalcemia of cancer,² ³ ⁴ ⁵ and two groups have identified.

Original language	English
Pages (from-to)	556-563
Number of pages	8
Journal	New England Journal of Medicine
Volume	319
Issue number	9
DOIs	https://doi.org/10.1056/NEJM198809013190906
State	Published - 1 Sep 1988
Externally published	Yes

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title = "Humoral Hypercalcemia of Cancer",

abstract = "THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.1 When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that the tumor was secreting parathyroid hormone or a peptide with similar actions. Interest in this syndrome has persisted, and has become particularly intense during the past decade. In the past six months, three groups have isolated and partially sequenced the amino terminus of a parathyroid hormone-like peptide obtained from four different tumors associated with humoral hypercalcemia of cancer,2 3 4 5 and two groups have identified.",

author = "Flier, {Jeffrey S.} and Underhill, {Lisa H.} and Broadus, {Arthur E.} and Marguerite Mangin and Kyoji Ikeda and Insogna, {Karl L.} and Weir, {Eleanor C.} and Burtis, {William J.} and Stewart, {Andrew F.}",

year = "1988",

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language = "English",

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TY - JOUR

T1 - Humoral Hypercalcemia of Cancer

AU - Flier, Jeffrey S.

AU - Underhill, Lisa H.

AU - Broadus, Arthur E.

AU - Mangin, Marguerite

AU - Ikeda, Kyoji

AU - Insogna, Karl L.

AU - Weir, Eleanor C.

AU - Burtis, William J.

AU - Stewart, Andrew F.

PY - 1988/9/1

Y1 - 1988/9/1

N2 - THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.1 When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that the tumor was secreting parathyroid hormone or a peptide with similar actions. Interest in this syndrome has persisted, and has become particularly intense during the past decade. In the past six months, three groups have isolated and partially sequenced the amino terminus of a parathyroid hormone-like peptide obtained from four different tumors associated with humoral hypercalcemia of cancer,2 3 4 5 and two groups have identified.

AB - THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.1 When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that the tumor was secreting parathyroid hormone or a peptide with similar actions. Interest in this syndrome has persisted, and has become particularly intense during the past decade. In the past six months, three groups have isolated and partially sequenced the amino terminus of a parathyroid hormone-like peptide obtained from four different tumors associated with humoral hypercalcemia of cancer,2 3 4 5 and two groups have identified.

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DO - 10.1056/NEJM198809013190906

M3 - Review article

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AN - SCOPUS:0023677625

SN - 0028-4793

VL - 319

SP - 556

EP - 563

JO - New England Journal of Medicine

JF - New England Journal of Medicine

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ER -

Humoral Hypercalcemia of Cancer

Abstract

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