Humoral Hypercalcemia of Cancer

Jeffrey S. Flier, Lisa H. Underhill, Arthur E. Broadus, Marguerite Mangin, Kyoji Ikeda, Karl L. Insogna, Eleanor C. Weir, William J. Burtis, Andrew F. Stewart

Research output: Contribution to journalReview articlepeer-review

340 Scopus citations


THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.1 When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that the tumor was secreting parathyroid hormone or a peptide with similar actions. Interest in this syndrome has persisted, and has become particularly intense during the past decade. In the past six months, three groups have isolated and partially sequenced the amino terminus of a parathyroid hormone-like peptide obtained from four different tumors associated with humoral hypercalcemia of cancer,2 3 4 5 and two groups have identified.

Original languageEnglish
Pages (from-to)556-563
Number of pages8
JournalNew England Journal of Medicine
Issue number9
StatePublished - 1 Sep 1988
Externally publishedYes


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