TY - JOUR
T1 - Human Virus Transcriptional Regulators
AU - Liu, Xing
AU - Hong, Ted
AU - Parameswaran, Sreeja
AU - Ernst, Kevin
AU - Marazzi, Ivan
AU - Weirauch, Matthew T.
AU - Fuxman Bass, Juan I.
N1 - Funding Information:
We apologize to the many colleagues whose important primary studies could not be cited due to space constraints. We thank Xiaoting Chen and Michael Lape for computational support. We thank Carmy Forney, Mariano Garcia-Blanco, Thomas Gilmore, Jun Young Hong, Jeffrey Johnson, Leah Kottyan, William Miller, Emily Miraldi, Nancy Sawtell, Trevor Siggers, Richard Thompson, Stephen Waggoner, David Waxman, and Susanne Wells for critical feedback on the manuscript. This work was supported by NIH ( R35 GM128625 to J.I.F.B. and R01 NS099068 , R01 AR073228 , R01 GM055479 , R01 HG010730 , and R21 HG008186 to M.T.W.) and by Cincinnati Children’s Hospital “ Trustee Award ,” “ Center for Pediatric Genomics Award ,” and “ CCRF Endowed Scholar Award ” to M.T.W.
Funding Information:
We apologize to the many colleagues whose important primary studies could not be cited due to space constraints. We thank Xiaoting Chen and Michael Lape for computational support. We thank Carmy Forney, Mariano Garcia-Blanco, Thomas Gilmore, Jun Young Hong, Jeffrey Johnson, Leah Kottyan, William Miller, Emily Miraldi, Nancy Sawtell, Trevor Siggers, Richard Thompson, Stephen Waggoner, David Waxman, and Susanne Wells for critical feedback on the manuscript. This work was supported by NIH (R35 GM128625 to J.I.F.B. and R01 NS099068, R01 AR073228, R01 GM055479, R01 HG010730, and R21 HG008186 to M.T.W.) and by Cincinnati Children's Hospital ?Trustee Award,? ?Center for Pediatric Genomics Award,? and ?CCRF Endowed Scholar Award? to M.T.W.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/7/9
Y1 - 2020/7/9
N2 - Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
AB - Viral genomes encode transcriptional regulators that alter the expression of viral and host genes. Despite an emerging role in human diseases, a thorough annotation of human viral transcriptional regulators (vTRs) is currently lacking, limiting our understanding of their molecular features and functions. Here, we provide a comprehensive catalog of 419 vTRs belonging to 20 different virus families. Using this catalog, we characterize shared and unique cellular genes, proteins, and pathways targeted by particular vTRs and discuss the role of vTRs in human disease pathogenesis. Our study provides a unique and valuable resource for the fields of virology, genomics, and human disease genetics.
UR - http://www.scopus.com/inward/record.url?scp=85087381934&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2020.06.023
DO - 10.1016/j.cell.2020.06.023
M3 - Review article
C2 - 32649876
AN - SCOPUS:85087381934
SN - 0092-8674
VL - 182
SP - 24
EP - 37
JO - Cell
JF - Cell
IS - 1
ER -