Human type I procollagen genes are located on different chromosomes

C. Huerre; C. Junien; D. Weil; M. L. Chu; M. Morabito; N. Van Cong; J. C. Myers; C. Foubert; M. S. Gross; D. J. Prockop; A. Boué; J. C. Kaplan; A. de la Chapelle; F. Ramirez

doi:10.1073/pnas.79.21.6627

Human type I procollagen genes are located on different chromosomes

C. Huerre
, C. Junien
, D. Weil
, M. L. Chu
, M. Morabito
, N. Van Cong
, J. C. Myers
, C. Foubert
, M. S. Gross
, D. J. Prockop
, A. Boué
, J. C. Kaplan
, A. de la Chapelle
, F. Ramirez

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

Original language	English
Pages (from-to)	6627-6630
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	21 I
DOIs	https://doi.org/10.1073/pnas.79.21.6627
State	Published - 1982

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Huerre, C., Junien, C., Weil, D., Chu, M. L., Morabito, M., Van Cong, N., Myers, J. C., Foubert, C., Gross, M. S., Prockop, D. J., Boué, A., Kaplan, J. C., de la Chapelle, A., & Ramirez, F. (1982). Human type I procollagen genes are located on different chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 79(21 I), 6627-6630. https://doi.org/10.1073/pnas.79.21.6627

@article{bd36ff8cfba64ab3bf069b32d502e16b,

title = "Human type I procollagen genes are located on different chromosomes",

abstract = "A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.",

author = "C. Huerre and C. Junien and D. Weil and Chu, \{M. L.\} and M. Morabito and \{Van Cong\}, N. and Myers, \{J. C.\} and C. Foubert and Gross, \{M. S.\} and Prockop, \{D. J.\} and A. Bou{\'e} and Kaplan, \{J. C.\} and \{de la Chapelle\}, A. and F. Ramirez",

year = "1982",

doi = "10.1073/pnas.79.21.6627",

language = "English",

volume = "79",

pages = "6627--6630",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "21 I",

}

Huerre, C, Junien, C, Weil, D, Chu, ML, Morabito, M, Van Cong, N, Myers, JC, Foubert, C, Gross, MS, Prockop, DJ, Boué, A, Kaplan, JC, de la Chapelle, A & Ramirez, F 1982, 'Human type I procollagen genes are located on different chromosomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 21 I, pp. 6627-6630. https://doi.org/10.1073/pnas.79.21.6627

TY - JOUR

T1 - Human type I procollagen genes are located on different chromosomes

AU - Huerre, C.

AU - Junien, C.

AU - Weil, D.

AU - Chu, M. L.

AU - Morabito, M.

AU - Van Cong, N.

AU - Myers, J. C.

AU - Foubert, C.

AU - Gross, M. S.

AU - Prockop, D. J.

AU - Boué, A.

AU - Kaplan, J. C.

AU - de la Chapelle, A.

AU - Ramirez, F.

PY - 1982

Y1 - 1982

N2 - A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

AB - A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

UR - https://www.scopus.com/pages/publications/0020451570

U2 - 10.1073/pnas.79.21.6627

DO - 10.1073/pnas.79.21.6627

M3 - Article

C2 - 6292910

AN - SCOPUS:0020451570

SN - 0027-8424

VL - 79

SP - 6627

EP - 6630

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 21 I

ER -

Human type I procollagen genes are located on different chromosomes

Abstract

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