Human type I procollagen genes are located on different chromosomes

C. Huerre; C. Junien; D. Weil; M. L. Chu; M. Morabito; N. Van Cong; J. C. Myers; C. Foubert; M. S. Gross; D. J. Prockop; A. Boué; J. C. Kaplan; A. de la Chapelle; F. Ramirez

doi:10.1073/pnas.79.21.6627

Human type I procollagen genes are located on different chromosomes

C. Huerre, C. Junien, D. Weil, M. L. Chu, M. Morabito, N. Van Cong, J. C. Myers, C. Foubert, M. S. Gross, D. J. Prockop, A. Boué, J. C. Kaplan, A. de la Chapelle, F. Ramirez

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Abstract

A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

Original language	English
Pages (from-to)	6627-6630
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	79
Issue number	21 I
DOIs	https://doi.org/10.1073/pnas.79.21.6627
State	Published - 1982

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Huerre, C., Junien, C., Weil, D., Chu, M. L., Morabito, M., Van Cong, N., Myers, J. C., Foubert, C., Gross, M. S., Prockop, D. J., Boué, A., Kaplan, J. C., de la Chapelle, A., & Ramirez, F. (1982). Human type I procollagen genes are located on different chromosomes. Proceedings of the National Academy of Sciences of the United States of America, 79(21 I), 6627-6630. https://doi.org/10.1073/pnas.79.21.6627

@article{bd36ff8cfba64ab3bf069b32d502e16b,

title = "Human type I procollagen genes are located on different chromosomes",

abstract = "A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.",

author = "C. Huerre and C. Junien and D. Weil and Chu, {M. L.} and M. Morabito and {Van Cong}, N. and Myers, {J. C.} and C. Foubert and Gross, {M. S.} and Prockop, {D. J.} and A. Bou{\'e} and Kaplan, {J. C.} and {de la Chapelle}, A. and F. Ramirez",

year = "1982",

doi = "10.1073/pnas.79.21.6627",

language = "English",

volume = "79",

pages = "6627--6630",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "21 I",

}

Huerre, C, Junien, C, Weil, D, Chu, ML, Morabito, M, Van Cong, N, Myers, JC, Foubert, C, Gross, MS, Prockop, DJ, Boué, A, Kaplan, JC, de la Chapelle, A & Ramirez, F 1982, 'Human type I procollagen genes are located on different chromosomes', Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 21 I, pp. 6627-6630. https://doi.org/10.1073/pnas.79.21.6627

TY - JOUR

T1 - Human type I procollagen genes are located on different chromosomes

AU - Huerre, C.

AU - Junien, C.

AU - Weil, D.

AU - Chu, M. L.

AU - Morabito, M.

AU - Van Cong, N.

AU - Myers, J. C.

AU - Foubert, C.

AU - Gross, M. S.

AU - Prockop, D. J.

AU - Boué, A.

AU - Kaplan, J. C.

AU - de la Chapelle, A.

AU - Ramirez, F.

PY - 1982

Y1 - 1982

N2 - A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

AB - A recombinant plasmid containing sequences complementary to human pro-α1(I) collagen mRNA was used for the chromosomal assignment of the pro-α1(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosome with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-α1(I) gene with the segment 17q21→qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.

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U2 - 10.1073/pnas.79.21.6627

DO - 10.1073/pnas.79.21.6627

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C2 - 6292910

AN - SCOPUS:0020451570

SN - 0027-8424

VL - 79

SP - 6627

EP - 6630

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 21 I

ER -

Human type I procollagen genes are located on different chromosomes

Abstract

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