Human T follicular helper cells: Development and subsets

Nathalie Schmitt, Hideki Ueno

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

28 Scopus citations

Abstract

Antibody response constitutes one of the key immune protection mechanisms. T follicular helper (Tfh) cells represent the major CD4+ T cell subset that provides help to B cells to induce antibody response. How Tfh cells develop and how Tfh cells or their associated subsets regulate antibody response in humans remains largely unknown. In this review, we will summarize the recent discoveries on the biology of Tfh cells, with a particular focus on human Tfh cells.

Original languageEnglish
Title of host publicationCrossroads Between Innate and Adaptive Immunity IV
PublisherSpringer New York LLC
Pages87-94
Number of pages8
ISBN (Print)9781461462163
DOIs
StatePublished - 2013
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume785
ISSN (Print)0065-2598

Keywords

  • Antibody response
  • Autoimmune diseases
  • Blood
  • CXCR5
  • Human
  • T follicular helper cells
  • Tonsils

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