Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy

Toco Y.P. Chui; Shelley Mo; Brian Krawitz; Nikhil R. Menon; Nadim Choudhury; Alexander Gan; Moataz Razeen; Nishit Shah; Alexander Pinhas; Richard B. Rosen

doi:10.1186/s40942-016-0037-8

Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy

Toco Y.P. Chui, Shelley Mo, Brian Krawitz, Nikhil R. Menon, Nadim Choudhury, Alexander Gan, Moataz Razeen, Nishit Shah, Alexander Pinhas, Richard B. Rosen

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Background: Retinal microvascular imaging is an especially promising application of high resolution imaging since there are increasing options for therapeutic intervention and need for better structural and functional biomarkers to characterize ocular and systemic vascular diseases. Main body: Adaptive optics scanning light ophthalmoscopy (AOSLO) is an emerging technology for improving in vivo imaging of the human retinal microvasculature, allowing unprecedented visualization of retinal microvascular structure, measurements of blood flow velocity, and microvascular network mapping. This high resolution imaging technique shows significant potential for studying physiological and pathological conditions of the retinal microvasculature noninvasively. Conclusion: This review will briefly summarize the abilities of in vivo human retinal microvasculature imaging in healthy controls, as well as patients with diabetic retinopathy, retinal vein occlusion, and sickle cell retinopathy using AOSLO and discuss its potential contribution to scientific research and clinical applications.

Original language	English
Article number	11
Journal	International Journal of Retina and Vitreous
Volume	2
Issue number	1
DOIs	https://doi.org/10.1186/s40942-016-0037-8
State	Published - 12 Dec 2016

Keywords

Adaptive optics
Blood vessels
Capillaries
Diabetic retinopathy
Fluorescein angiography
Retina
Retinal vein occlusion
Sickle cell retinopathy

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10.1186/s40942-016-0037-8

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title = "Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy",

abstract = "Background: Retinal microvascular imaging is an especially promising application of high resolution imaging since there are increasing options for therapeutic intervention and need for better structural and functional biomarkers to characterize ocular and systemic vascular diseases. Main body: Adaptive optics scanning light ophthalmoscopy (AOSLO) is an emerging technology for improving in vivo imaging of the human retinal microvasculature, allowing unprecedented visualization of retinal microvascular structure, measurements of blood flow velocity, and microvascular network mapping. This high resolution imaging technique shows significant potential for studying physiological and pathological conditions of the retinal microvasculature noninvasively. Conclusion: This review will briefly summarize the abilities of in vivo human retinal microvasculature imaging in healthy controls, as well as patients with diabetic retinopathy, retinal vein occlusion, and sickle cell retinopathy using AOSLO and discuss its potential contribution to scientific research and clinical applications.",

keywords = "Adaptive optics, Blood vessels, Capillaries, Diabetic retinopathy, Fluorescein angiography, Retina, Retinal vein occlusion, Sickle cell retinopathy",

author = "Chui, {Toco Y.P.} and Shelley Mo and Brian Krawitz and Menon, {Nikhil R.} and Nadim Choudhury and Alexander Gan and Moataz Razeen and Nishit Shah and Alexander Pinhas and Rosen, {Richard B.}",

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doi = "10.1186/s40942-016-0037-8",

language = "English",

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AU - Chui, Toco Y.P.

AU - Mo, Shelley

AU - Krawitz, Brian

AU - Menon, Nikhil R.

AU - Choudhury, Nadim

AU - Gan, Alexander

AU - Razeen, Moataz

AU - Shah, Nishit

AU - Pinhas, Alexander

AU - Rosen, Richard B.

PY - 2016/12/12

Y1 - 2016/12/12

N2 - Background: Retinal microvascular imaging is an especially promising application of high resolution imaging since there are increasing options for therapeutic intervention and need for better structural and functional biomarkers to characterize ocular and systemic vascular diseases. Main body: Adaptive optics scanning light ophthalmoscopy (AOSLO) is an emerging technology for improving in vivo imaging of the human retinal microvasculature, allowing unprecedented visualization of retinal microvascular structure, measurements of blood flow velocity, and microvascular network mapping. This high resolution imaging technique shows significant potential for studying physiological and pathological conditions of the retinal microvasculature noninvasively. Conclusion: This review will briefly summarize the abilities of in vivo human retinal microvasculature imaging in healthy controls, as well as patients with diabetic retinopathy, retinal vein occlusion, and sickle cell retinopathy using AOSLO and discuss its potential contribution to scientific research and clinical applications.

AB - Background: Retinal microvascular imaging is an especially promising application of high resolution imaging since there are increasing options for therapeutic intervention and need for better structural and functional biomarkers to characterize ocular and systemic vascular diseases. Main body: Adaptive optics scanning light ophthalmoscopy (AOSLO) is an emerging technology for improving in vivo imaging of the human retinal microvasculature, allowing unprecedented visualization of retinal microvascular structure, measurements of blood flow velocity, and microvascular network mapping. This high resolution imaging technique shows significant potential for studying physiological and pathological conditions of the retinal microvasculature noninvasively. Conclusion: This review will briefly summarize the abilities of in vivo human retinal microvasculature imaging in healthy controls, as well as patients with diabetic retinopathy, retinal vein occlusion, and sickle cell retinopathy using AOSLO and discuss its potential contribution to scientific research and clinical applications.

KW - Adaptive optics

KW - Blood vessels

KW - Capillaries

KW - Diabetic retinopathy

KW - Fluorescein angiography

KW - Retina

KW - Retinal vein occlusion

KW - Sickle cell retinopathy

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DO - 10.1186/s40942-016-0037-8

M3 - Review article

AN - SCOPUS:85012274512

SN - 2056-9920

VL - 2

JO - International Journal of Retina and Vitreous

JF - International Journal of Retina and Vitreous

IS - 1

M1 - 11

ER -

Human retinal microvascular imaging using adaptive optics scanning light ophthalmoscopy

Abstract

Keywords

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