Human Platelets: Amino Acid Synthesis

Elena Puszkin; Louis Aledort; Saul Puszkin

doi:10.3181/00379727-131-34018

Human Platelets: Amino Acid Synthesis

Elena Puszkin
, Louis Aledort
, Saul Puszkin

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The rapid incorporation of labeled ¹⁴C from U^-14C-acetate and U^-14Câ€� Dâ€�glucose into free glutamic acid, glutamine, aspartic acid, and asparagine shows that human platelets are capable of synthesizing their own amino acids. Differences in the turnover rates of these amino acids indicate that the metabolic pools are localized in compartments. It is also suggested that more than one pool of acetyl CoA and probably at least two separate pools of citric acid cycle intermediates exist.

Original language	English
Pages (from-to)	957-959
Number of pages	3
Journal	Experimental Biology and Medicine
Volume	131
Issue number	3
DOIs	https://doi.org/10.3181/00379727-131-34018
State	Published - Jul 1969
Externally published	Yes

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@article{3af205767cdb4ce097705877965a88dc,

title = "Human Platelets: Amino Acid Synthesis",

abstract = "The rapid incorporation of labeled 14C from U-14C-acetate and U-14C{\^a}€� D{\^a}€�glucose into free glutamic acid, glutamine, aspartic acid, and asparagine shows that human platelets are capable of synthesizing their own amino acids. Differences in the turnover rates of these amino acids indicate that the metabolic pools are localized in compartments. It is also suggested that more than one pool of acetyl CoA and probably at least two separate pools of citric acid cycle intermediates exist.",

author = "Elena Puszkin and Louis Aledort and Saul Puszkin",

note = "Funding Information: This research was aided in part by USPHS Contract PH-43-67-1359 and Grant 5 RO1 HE 10905 from the National Heart Institute to the Division of Hematology, Department of Medicine, Mount Sinai School of Medicine, by the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Funds.",

year = "1969",

month = jul,

doi = "10.3181/00379727-131-34018",

language = "English",

volume = "131",

pages = "957--959",

journal = "Experimental Biology and Medicine",

issn = "0037-9727",

publisher = "Frontiers Media SA",

number = "3",

}

TY - JOUR

T1 - Human Platelets

T2 - Amino Acid Synthesis

AU - Puszkin, Elena

AU - Aledort, Louis

AU - Puszkin, Saul

N1 - Funding Information: This research was aided in part by USPHS Contract PH-43-67-1359 and Grant 5 RO1 HE 10905 from the National Heart Institute to the Division of Hematology, Department of Medicine, Mount Sinai School of Medicine, by the Albert A. List, Frederick Machlin, and Anna Ruth Lowenberg Funds.

PY - 1969/7

Y1 - 1969/7

N2 - The rapid incorporation of labeled 14C from U-14C-acetate and U-14Câ€� Dâ€�glucose into free glutamic acid, glutamine, aspartic acid, and asparagine shows that human platelets are capable of synthesizing their own amino acids. Differences in the turnover rates of these amino acids indicate that the metabolic pools are localized in compartments. It is also suggested that more than one pool of acetyl CoA and probably at least two separate pools of citric acid cycle intermediates exist.

AB - The rapid incorporation of labeled 14C from U-14C-acetate and U-14Câ€� Dâ€�glucose into free glutamic acid, glutamine, aspartic acid, and asparagine shows that human platelets are capable of synthesizing their own amino acids. Differences in the turnover rates of these amino acids indicate that the metabolic pools are localized in compartments. It is also suggested that more than one pool of acetyl CoA and probably at least two separate pools of citric acid cycle intermediates exist.

UR - https://www.scopus.com/pages/publications/0014545455

U2 - 10.3181/00379727-131-34018

DO - 10.3181/00379727-131-34018

M3 - Article

C2 - 5791814

AN - SCOPUS:0014545455

SN - 0037-9727

VL - 131

SP - 957

EP - 959

JO - Experimental Biology and Medicine

JF - Experimental Biology and Medicine

IS - 3

ER -

Human Platelets: Amino Acid Synthesis

Abstract

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