TY - JOUR
T1 - Human papillomavirus types and cervical squamous intraepithelial lesions that recur after cold-knife conization
AU - Nuovo, Gerard
AU - Moritz, Jacques
AU - Kowalik, Ania
AU - Chalas, Eva
AU - Kaplan, Benjamin
AU - Mann, William
N1 - Funding Information:
This study is supportedb y grants from the Lewis Foundation and Life Technologies,I nc., to G.J.N. The authors greatly appreciatet he invaluable assistanceo f Marlene Darfler and Dr. Susan Bromley, the editorial advice of Ms. Phyllis MacConnell, and the continueds upport of Mr. S. B. Lewis.
PY - 1992/9
Y1 - 1992/9
N2 - The purpose of this study was to analyze the HPV types and histological margins of cervical squamous intraepithelial lesions (SILs) treated by cold-knife conization and to correlate this with recurrent disease. Of 203 cone biopsies done for SILs primarily because the entire lesion could not be visualized at colposcopy, follow-up information was available for 85 cases. Of these 85 cases, biopsy-proven recurrences were documented for 10 (12%) women. In the SILs which recurred after conization, the lesion was noted on the surgical margin in 7 10 (70%) cases. In contrast, SILs that did not recur after cold-knife conization were detected on the surgical margin in only 12% of cases. In 7 of the recurrences, the HPV type detected in the pretreatment SIL was the same as that detected in the SIL that occurred after conization. In the other 3 recurrences, one of either the primary or recurrent SILs was HPV positive and the other corresponding lesion HPV negative. It is concluded that detection of a SIL on the surgical margin is a marker for recurrent disease and that recurrences are often associated with the same HPV type as that noted in the pretreatment SIL.
AB - The purpose of this study was to analyze the HPV types and histological margins of cervical squamous intraepithelial lesions (SILs) treated by cold-knife conization and to correlate this with recurrent disease. Of 203 cone biopsies done for SILs primarily because the entire lesion could not be visualized at colposcopy, follow-up information was available for 85 cases. Of these 85 cases, biopsy-proven recurrences were documented for 10 (12%) women. In the SILs which recurred after conization, the lesion was noted on the surgical margin in 7 10 (70%) cases. In contrast, SILs that did not recur after cold-knife conization were detected on the surgical margin in only 12% of cases. In 7 of the recurrences, the HPV type detected in the pretreatment SIL was the same as that detected in the SIL that occurred after conization. In the other 3 recurrences, one of either the primary or recurrent SILs was HPV positive and the other corresponding lesion HPV negative. It is concluded that detection of a SIL on the surgical margin is a marker for recurrent disease and that recurrences are often associated with the same HPV type as that noted in the pretreatment SIL.
UR - https://www.scopus.com/pages/publications/0026655569
U2 - 10.1016/0090-8258(92)90221-4
DO - 10.1016/0090-8258(92)90221-4
M3 - Article
C2 - 1326471
AN - SCOPUS:0026655569
SN - 0090-8258
VL - 46
SP - 304
EP - 308
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -