Human papillomavirus-associated lesions of the vagina and cervix: Treatment with a laser and topical 5-fluorouracil

M. Brodman, P. Dottino, F. Friedman, D. Heller, I. Bleiweiss, R. Sperling

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Twenty women with cervical and vaginal human papillomavirus-associated lesions were treated with CO2 laser ablation followed by eight weekly applications of 5-fluorouracil. Viral subtyping in a majority of patients and histology were obtained before and after treatment. After treatment 88% (15 of 17) had normal vaginal biopsies, and 59% (10 of 17) had normal cervical biopsies. There were no treatment failures with subtype 6/11 infection of the cervix or vagina. All the failures were with viral subtypes 16/18 and 31/35/51. The protocol was effective in treating patients with cervical and vaginal human papillomavirus-associated lesions.

Original languageEnglish
Pages (from-to)453-456
Number of pages4
JournalThe Journal of reproductive medicine
Volume37
Issue number5
StatePublished - 1992

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