Human Oncoprotein MDM2 Up-regulates Expression of NF-κB2 Precursor p100 Conferring a Survival Advantage to Lung Cells

Keyphrases

• Oncoprotein 100%
• Lung Cells 100%
• Survival Benefit 100%
• P100 100%
• Murine Double Minute 2 (MDM2) 100%
• Knockdown 11%
• Overexpression 11%
• Wild-type p53 11%
• Lung Cancer Cells 11%
• Interaction Domains 11%
• Human Lung Tumors 11%
• Cell Death 5%
• In Cancer 5%
• Oncogenesis 5%
• Transgenic Mice 5%
• Tumor 5%
• Cell Proliferation 5%
• Biological Function 5%
• Littermate 5%
• CXCL10 5%
• Physiological Role 5%
• P53 Expression 5%
• Opposite Effects 5%
• P53 Status 5%
• Paclitaxel 5%
• Transactivation 5%
• Reduced Expression 5%
• Direct Interaction 5%
• Reduced Cell 5%
• Enhanced Expression 5%
• Statistical Correlation 5%
• Functional Domain 5%
• Non-transgenic 5%
• MDM2-p53 Interaction 5%
• Nutlin-3 5%
• CXCL1 5%
• Mechanism Function 5%
• Lung Tumor Cells 5%

Biochemistry, Genetics and Molecular Biology

• Precursor 100%
• P53 100%
• Upregulation 30%
• Promoter Region 20%
• Cancer Cell 20%
• Wild Type 20%
• Cell Death 10%
• Transcription 10%
• Cell Proliferation 10%
• Carcinogenesis 10%
• Transgenic Mouse 10%
• Transgenics 10%
• Biological Functions 10%
• Transactivation 10%
• Nutlin 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein P53 100%
• Protein MDM2 100%
• Lung Tumor 30%
• Elimination 20%
• Lung Cancer 20%
• Carcinogenesis 10%
• Transgenic Mouse 10%
• Paclitaxel 10%
• Nutlin 3 10%