Human monocytes in culture synthesize and secrete lipoprotein lipase

Patsy Wang-Iverson, Anne Ungar, Jemiliya Bliumis, Phillip R. Bukberg, Joyce C. Gibson, W. Virgil Brown

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Within the first day in culture, human monocytes begin to synthesize and secrete a triglyceride lipase. The designation of this activity as lipoprotein lipase is based upon: 1) a requirement of serum or apolipoprotein C-II for full activity; 2) inhibition by 1M NaCl or apolipoprotein C-III2; 3) a pH optimum of 8; and 4) binding to endothelial cells that is releasable by heparin. The enzyme also exhibits immunological cross reactivity with antibody to purified bovine milk lipoprotein lipase as does human postheparin plasma lipoprotein lipase. Lymphocytes and polymorphonuclear leukocytes do not appear to contain this enzyme.

Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - 11 Feb 1982


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