TY - JOUR
T1 - Human melatonin suppression by light
T2 - A case for scotopic efficiency
AU - Rea, Mark S.
AU - Bullough, John D.
AU - Figueiro, Mariana G.
N1 - Funding Information:
This work was supported by Philips Lighting, Niagara Mohawk Power Corporation, Northeast Utilities and the Electric Power Research Institute. Lutron Electronics supplied the dimming ballasts used in this study. The assistance and advice of Peter Boyce, Richard Pysar, Nishantha Maliyagoda, Andrew Bierman, Marylou Nickleson, Daniel Dyer, Robert Lingard, Krzysztof Kryszczuk, Rohini Pendyala, S.H.A. Begemann, Gerrit van der Beld, Peter Morante, John Kesselring, and Benjamin Koyle are also gratefully acknowledged.
PY - 2001/2/16
Y1 - 2001/2/16
N2 - Human adult males were exposed to combinations of two illuminances and two spectral power distributions over the course of four nighttime sessions. A dose-dependent response of acute melatonin suppression to light was found, but photopic (cone-based) illuminance did not adequately predict suppression. When melatonin suppression was plotted against scotopic (rod-based) illuminance, the data formed a nearly monotonic function, implicating rods, or a rod-dominated mechanism, in the human melatonin regulation system. The results do not, however, rule out mechanisms other than rods, including novel photoreceptors, as candidates for melatonin regulation in humans.
AB - Human adult males were exposed to combinations of two illuminances and two spectral power distributions over the course of four nighttime sessions. A dose-dependent response of acute melatonin suppression to light was found, but photopic (cone-based) illuminance did not adequately predict suppression. When melatonin suppression was plotted against scotopic (rod-based) illuminance, the data formed a nearly monotonic function, implicating rods, or a rod-dominated mechanism, in the human melatonin regulation system. The results do not, however, rule out mechanisms other than rods, including novel photoreceptors, as candidates for melatonin regulation in humans.
KW - Circadian rhythm
KW - Photoreceptive system
KW - Pineal response
KW - Spectral sensitivity
UR - http://www.scopus.com/inward/record.url?scp=0035895768&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)01512-9
DO - 10.1016/S0304-3940(01)01512-9
M3 - Article
C2 - 11166934
AN - SCOPUS:0035895768
SN - 0304-3940
VL - 299
SP - 45
EP - 48
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -