Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping

Sara Trabanelli, Alejandra Gomez-Cadena, Bérengère Salomé, Katarzyna Michaud, Domenico Mavilio, Basile Nicolas Landis, Peter Jandus, Camilla Jandus

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2, and ILC3, that can be specifically activated by different signals coming either indirectly from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions. The discovery and the study of these immune cells is now offering important opportunities for innovative therapies of allergic airway diseases, inflammatory disorders and might be crucial for the discovery of new targets for the therapy of cancer. It is therefore fundamental that the scientific community establishes harmonized guidelines to obtain a consensus in the identification and phenotypical and functional characterization of ILCs.

Original languageEnglish
Pages (from-to)392-399
Number of pages8
JournalCytometry Part B - Clinical Cytometry
Volume94
Issue number3
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • allergy
  • flow cytometry
  • immune monitoring
  • innate lymphoid cells
  • leukemia
  • phenotype

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