Human infections with Mycobacterium bovis

B. Damsker, E. J. Bottone, S. S. Schneierson

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Two patients with tuberculosis due to Mycobacterium bovis were identified at The Mount Sinai Hospital from 1970 through 1973. In addition, 2 isolates of M. bovis BCG were recovered from abscesses at vaccination sites of nontuberculous patients. All 4 strains were slow growers, produced nonpigmented, rough colonies, and demonstrated cording. Initial isolation was best achieved in media devoid of glycerol. The 2 wild M. bovis strains were dysgonic, inhibited by glycerol, niacin and nitrate negative, and susceptible to the action of thiophene 2 carboxylic acid hydrazide (TCH). One of them was found to be pathogenic for rabbits. After rabbit passage, this strain became eugonic, producing luxuriant growth of larger, smoother colonies on Lowenstein Jensen (L J) and Middlebrook 7H11 agars, and inconsistently niacin positive. The 2 isolates of M. bovis BCG were not inhibited by glycerol, as evidenced by eugonic growth on L J and 7H11, but were niacin and nitrate negative and susceptible to TCH.

Original languageEnglish
Pages (from-to)446-449
Number of pages4
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number4
StatePublished - 1974
Externally publishedYes


Dive into the research topics of 'Human infections with Mycobacterium bovis'. Together they form a unique fingerprint.

Cite this