Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer

Chia ching J. Wang, Joseph Sparano, Joel M. Palefsky

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


Anal cancer is an increasingly common non–AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index.

Original languageEnglish
Pages (from-to)17-31
Number of pages15
JournalSurgical Oncology Clinics of North America
Issue number1
StatePublished - 1 Jan 2017
Externally publishedYes


  • Anal cancer
  • HIV
  • HPV
  • HPV vaccination
  • Immunosuppression


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