Human immunodeficiency virus-1 infection of the lymphoid tissues of Waldeyer's ring

Sarah S. Frankel, Bruch M. Wenig, Alfio Ferlito

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10 Scopus citations


Human immunodeficiency virus-1 (HIV-1) infection is a fatal retroviral infection that may first present clinically as enlargement of the lymphoid tissues of Waldeyer's ring. These tissues are a major site of viral replication. The presence of the virus in these tissues causes a unique constellation of diagnostic histopathologic features, including florid follicular hyperplasia, follicle lysis, and productively HIV-1-infected multinucleated giant cells of probable dendritic cell origin. Serologic evaluation is confirmatory of HIV infection. With the recent advances in antiretroviral chemotherapy, the early institution of which may significantly prolong life and disease-free interval, the recognition of the clinical and pathologic parameters of HIV-related enlargement of Waldeyer's ring tissues is essential.

Original languageEnglish
Pages (from-to)611-618
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Issue number7 II SUPPL. 169
StatePublished - 1997
Externally publishedYes


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