Human Immune Monitoring Techniques during Food Allergen Immunotherapy

Blake Rust, Erik Wambre

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Purpose of Review: Encouraging results from recent food allergen immunotherapy clinical trials indicate that the immune system plays an essential role in peripheral tolerance to food allergen. Thus, the monitoring of changes in immune responses and their possible correlation with clinical outcome in allergic patients receiving immunotherapies could theoretically serve as surrogate markers and be harnessed as rationale for food allergen immunotherapy development. Recent Findings: A shift towards antigen specificity in recent assays has provided a solid foundation for the elucidation of cellular mechanisms involved in food allergen immunotherapy as well as the tracking of allergen-specific immune cells. Summary: In this review, we overview the current challenges and technologies used in immune monitoring during immunotherapy in allergic patients with a focus on cell-mediated immunity. We also discuss critical steps involved in some of the cellular immune assays utilized in clinical trials.

Original languageEnglish
Article number22
JournalCurrent Allergy and Asthma Reports
Volume17
Issue number4
DOIs
StatePublished - 1 Apr 2017
Externally publishedYes

Keywords

  • Antigen-specific
  • Basophil activation
  • Effector T cells
  • Food allergy
  • Immunotherapy
  • Regulatory T cells

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