Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro

Saul W. Rosen, Janina Kaminska, Ida S. Calvert, Stuart A. Aaronson

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Normal and genetic variant strains of nonrnalignant human fibroblasts produce in vitro a substance indistinguishable from the recently described "pregnancy-specific" beta-1 gtycoprotein (PSβG, PAPP-C, SP1). Demonstration of this presumed placenta-specific meterial in a nonplacental site raises questions about its :normal physiologic role and use as a cancer marker.

Original languageEnglish
Pages (from-to)734-738
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number7
StatePublished - 1 Aug 1979
Externally publishedYes


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