Abstract
The DNA isolated from simian virus 40 (SV40) can transform human fibroblast cells in tissue culture. Clonal lines of DNA-transformed human cells have been obtained that have properties characteristic of cells transformed by whole virus. They all contain SV40 T-antigen, and infectious virus can be recovered by cocultivation. This is the first demonstration of a permanent genetic alteration produced in human cells by purified DNA.
| Original language | English |
|---|---|
| Pages (from-to) | 390-391 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 166 |
| Issue number | 3903 |
| DOIs | |
| State | Published - 1969 |
| Externally published | Yes |