TY - JOUR
T1 - Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression
AU - Vider, Ben Zion
AU - Zimber, Amazia
AU - Hirsch, Dania
AU - Estlein, Dov
AU - Chastre, Eric
AU - Prevot, Sophie
AU - Gespach, Christian
AU - Yaniv, Abraham
AU - Gazit, Arnona
PY - 1997/3/27
Y1 - 1997/3/27
N2 - In the present study, the possible involvement of homeobox-containing genes in colorectal cancer (CRC) development was investigated. Using a stepwise screening approach and RT-PCR, we have demonstrated that the human HOXB6, B8, C8 and C9 are overexpressed at various stages of CRC. In contrast, all CRC cases exhibited a marked decrease in the homeodomain-containing Cdx1 gene expression. Recent data which suggest a regulatory link between HOXB8 and several tumor suppressor genes, such as DCC, APC, and TGFβ, sustain a possible implication of homeobox genes in colon carcinogenesis. Moreover, our data showing a decrease in Cdx1 expression are consistent with the notion that genes functioning in the establishment and maintenance of the intestinal epithelium might, upon deregulation, disturb the normal control of cellular proliferation, differentiation, and death, thus leading to cancer development.
AB - In the present study, the possible involvement of homeobox-containing genes in colorectal cancer (CRC) development was investigated. Using a stepwise screening approach and RT-PCR, we have demonstrated that the human HOXB6, B8, C8 and C9 are overexpressed at various stages of CRC. In contrast, all CRC cases exhibited a marked decrease in the homeodomain-containing Cdx1 gene expression. Recent data which suggest a regulatory link between HOXB8 and several tumor suppressor genes, such as DCC, APC, and TGFβ, sustain a possible implication of homeobox genes in colon carcinogenesis. Moreover, our data showing a decrease in Cdx1 expression are consistent with the notion that genes functioning in the establishment and maintenance of the intestinal epithelium might, upon deregulation, disturb the normal control of cellular proliferation, differentiation, and death, thus leading to cancer development.
UR - http://www.scopus.com/inward/record.url?scp=0031587766&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1997.6364
DO - 10.1006/bbrc.1997.6364
M3 - Article
C2 - 9126347
AN - SCOPUS:0031587766
SN - 0006-291X
VL - 232
SP - 742
EP - 748
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -