Human chromosome 19 carries a poliovirus receptor gene

Dorothy A. Miller; Orlando J. Miller; Vaithllingam G. Dev; Shahnaz Hashmi; Ramana Tantravahi; Leandro Medrano; Howard Green

doi:10.1016/0092-8674(74)90108-1

Human chromosome 19 carries a poliovirus receptor gene

Dorothy A. Miller, Orlando J. Miller, Vaithllingam G. Dev, Shahnaz Hashmi, Ramana Tantravahi, Leandro Medrano, Howard Green

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

The chromosome complements of human/mouse hybrid cell lines of mouse 3T3-4E and RAG parentage have been analyzed using chromosome banding methods. Three lines that were susceptible to lytic infection with poliovirus contained eleven to seventeen human chromosomes, including chromosome 19. Polio-resistant sublines of these contained no chromosome 19 and showed no other consistent change in the complement of human chromosomes. Human chromosome 19 therefore is essential for polio-sensitivity. Since polio sensitivity was correlated with receptor activity in these lines, we conclude that chromosome 19 carries the structural gene for the poliovirus receptor. Sensitivity to echo-7 and Rhino-1A viruses could not be related to the presence of a specific human chromosome.

Original language	English
Pages (from-to)	167-173
Number of pages	7
Journal	Cell
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0092-8674(74)90108-1
State	Published - Apr 1974
Externally published	Yes

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@article{128c286cdd6a4d5096d2ae5ab3463dbb,

title = "Human chromosome 19 carries a poliovirus receptor gene",

abstract = "The chromosome complements of human/mouse hybrid cell lines of mouse 3T3-4E and RAG parentage have been analyzed using chromosome banding methods. Three lines that were susceptible to lytic infection with poliovirus contained eleven to seventeen human chromosomes, including chromosome 19. Polio-resistant sublines of these contained no chromosome 19 and showed no other consistent change in the complement of human chromosomes. Human chromosome 19 therefore is essential for polio-sensitivity. Since polio sensitivity was correlated with receptor activity in these lines, we conclude that chromosome 19 carries the structural gene for the poliovirus receptor. Sensitivity to echo-7 and Rhino-1A viruses could not be related to the presence of a specific human chromosome.",

author = "Miller, \{Dorothy A.\} and Miller, \{Orlando J.\} and Dev, \{Vaithllingam G.\} and Shahnaz Hashmi and Ramana Tantravahi and Leandro Medrano and Howard Green",

note = "Funding Information: This investigation was aided by grants from the National Foundation-March of Dimes, the National Cancer Institute, and the National Institute of General Medical Sciences. O.J.M. is a career scientist of the Health Research Council of the City of New York.",

year = "1974",

month = apr,

doi = "10.1016/0092-8674(74)90108-1",

language = "English",

volume = "1",

pages = "167--173",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - Human chromosome 19 carries a poliovirus receptor gene

AU - Miller, Dorothy A.

AU - Miller, Orlando J.

AU - Dev, Vaithllingam G.

AU - Hashmi, Shahnaz

AU - Tantravahi, Ramana

AU - Medrano, Leandro

AU - Green, Howard

N1 - Funding Information: This investigation was aided by grants from the National Foundation-March of Dimes, the National Cancer Institute, and the National Institute of General Medical Sciences. O.J.M. is a career scientist of the Health Research Council of the City of New York.

PY - 1974/4

Y1 - 1974/4

N2 - The chromosome complements of human/mouse hybrid cell lines of mouse 3T3-4E and RAG parentage have been analyzed using chromosome banding methods. Three lines that were susceptible to lytic infection with poliovirus contained eleven to seventeen human chromosomes, including chromosome 19. Polio-resistant sublines of these contained no chromosome 19 and showed no other consistent change in the complement of human chromosomes. Human chromosome 19 therefore is essential for polio-sensitivity. Since polio sensitivity was correlated with receptor activity in these lines, we conclude that chromosome 19 carries the structural gene for the poliovirus receptor. Sensitivity to echo-7 and Rhino-1A viruses could not be related to the presence of a specific human chromosome.

AB - The chromosome complements of human/mouse hybrid cell lines of mouse 3T3-4E and RAG parentage have been analyzed using chromosome banding methods. Three lines that were susceptible to lytic infection with poliovirus contained eleven to seventeen human chromosomes, including chromosome 19. Polio-resistant sublines of these contained no chromosome 19 and showed no other consistent change in the complement of human chromosomes. Human chromosome 19 therefore is essential for polio-sensitivity. Since polio sensitivity was correlated with receptor activity in these lines, we conclude that chromosome 19 carries the structural gene for the poliovirus receptor. Sensitivity to echo-7 and Rhino-1A viruses could not be related to the presence of a specific human chromosome.

UR - https://www.scopus.com/pages/publications/0016235121

U2 - 10.1016/0092-8674(74)90108-1

DO - 10.1016/0092-8674(74)90108-1

M3 - Article

AN - SCOPUS:0016235121

SN - 0092-8674

VL - 1

SP - 167

EP - 173

JO - Cell

JF - Cell

IS - 4

ER -

Human chromosome 19 carries a poliovirus receptor gene

Abstract

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