Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Sun Koo Yoo; Syed Faizan Mehdi; Suma Pusapati; Nimisha Mathur; Manasa Anipindi; Bruno Lunenfeld; Barbara Lowell; Huan Yang; Christine Noel Metz; Sawleha Arshi Khan; Derek Leroith; Jesse Roth

doi:10.3389/fimmu.2021.714177

Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Sun Koo Yoo, Syed Faizan Mehdi, Suma Pusapati, Nimisha Mathur, Manasa Anipindi, Bruno Lunenfeld, Barbara Lowell, Huan Yang, Christine Noel Metz, Sawleha Arshi Khan, Derek Leroith, Jesse Roth

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.

Original language	English
Article number	714177
Journal	Frontiers in Immunology
Volume	12
DOIs	https://doi.org/10.3389/fimmu.2021.714177
State	Published - 13 Sep 2021

Keywords

anti-inflammatory
cytokine storm
human chorionic gonadotrophic hormone (hCG)
inflammation
sepsis

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10.3389/fimmu.2021.714177

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title = "Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis",

abstract = "Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.",

keywords = "anti-inflammatory, cytokine storm, human chorionic gonadotrophic hormone (hCG), inflammation, sepsis",

author = "Yoo, {Sun Koo} and Mehdi, {Syed Faizan} and Suma Pusapati and Nimisha Mathur and Manasa Anipindi and Bruno Lunenfeld and Barbara Lowell and Huan Yang and Metz, {Christine Noel} and Khan, {Sawleha Arshi} and Derek Leroith and Jesse Roth",

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year = "2021",

month = sep,

day = "13",

doi = "10.3389/fimmu.2021.714177",

language = "English",

volume = "12",

journal = "Frontiers in Immunology",

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AU - Yoo, Sun Koo

AU - Mehdi, Syed Faizan

AU - Pusapati, Suma

AU - Mathur, Nimisha

AU - Anipindi, Manasa

AU - Lunenfeld, Bruno

AU - Lowell, Barbara

AU - Yang, Huan

AU - Metz, Christine Noel

AU - Khan, Sawleha Arshi

AU - Leroith, Derek

AU - Roth, Jesse

PY - 2021/9/13

Y1 - 2021/9/13

N2 - Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.

AB - Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.

KW - anti-inflammatory

KW - cytokine storm

KW - human chorionic gonadotrophic hormone (hCG)

KW - inflammation

KW - sepsis

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DO - 10.3389/fimmu.2021.714177

M3 - Review article

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SN - 1664-3224

VL - 12

JO - Frontiers in Immunology

JF - Frontiers in Immunology

M1 - 714177

ER -

Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Abstract

Keywords

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