TY - JOUR
T1 - Human brain evolution
T2 - Insights from microarrays
AU - Preuss, Todd M.
AU - Cáceres, Mario
AU - Oldham, Michael C.
AU - Geschwind, Daniel H.
N1 - Funding Information:
T.M.P. and M.C. contributed equally to this work. We thank the different authors of the primate microarray studies for making their data sets publicly available, James Thomas for the comparison of the array probes to the chimpanzee genome sequence, and David Kornack for his insightful comments. We would also like to thank the James S. McDonnell Foundation for their support of our research through a Collaborative Activities Grant (T.P., D.H.G.) and acknowledge support from the National Institute of Mental Health (D.H.G.).
PY - 2004/11
Y1 - 2004/11
N2 - Several recent microarray studies have compared gene-expression patterns n humans, chimpanzees and other non-human primates to identify evolutionary changes that contribute to the distinctive cognitive and behavioural characteristics of humans. These studies support the surprising conclusion that the evolution of the human brain involved an upregulation of gene expression relative to non-human primates, a finding that could be relevant to understanding human cerebral physiology and function. These results show how genetic and genomic methods can shed light on the basis of human neural and cognitive specializations, and have important implications for neuroscience, anthropology and medicine.
AB - Several recent microarray studies have compared gene-expression patterns n humans, chimpanzees and other non-human primates to identify evolutionary changes that contribute to the distinctive cognitive and behavioural characteristics of humans. These studies support the surprising conclusion that the evolution of the human brain involved an upregulation of gene expression relative to non-human primates, a finding that could be relevant to understanding human cerebral physiology and function. These results show how genetic and genomic methods can shed light on the basis of human neural and cognitive specializations, and have important implications for neuroscience, anthropology and medicine.
UR - http://www.scopus.com/inward/record.url?scp=7644239013&partnerID=8YFLogxK
U2 - 10.1038/nrg1469
DO - 10.1038/nrg1469
M3 - Review article
C2 - 15520794
AN - SCOPUS:7644239013
SN - 1471-0056
VL - 5
SP - 850
EP - 860
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 11
ER -