Human and parasitic Papain-like cysteine proteases: Their role in physiology and pathology and recent developments in inhibitor design

Fabien Lecaille, Jadwiga Kaleta, Dieter Brömme

Research output: Contribution to journalArticlepeer-review

462 Scopus citations

Abstract

Human... Based on the mechanism of peptide hydrolysis, five major protease classes are known: serine, cysteine, aspartic, threonine, and metallo-proteases. This review focuses on papain-like cysteine protease class. Topics discussed include the biochemistry of human and parasite cysteine proteases and recent developments in inhibitors design, as well as their role in physiology and pathology.

Original languageEnglish
Pages (from-to)4459-4488
Number of pages30
JournalChemical Reviews
Volume102
Issue number12
DOIs
StatePublished - Dec 2002

Fingerprint

Dive into the research topics of 'Human and parasitic Papain-like cysteine proteases: Their role in physiology and pathology and recent developments in inhibitor design'. Together they form a unique fingerprint.

Cite this