Human and parasitic Papain-like cysteine proteases: Their role in physiology and pathology and recent developments in inhibitor design

Human... Based on the mechanism of peptide hydrolysis, five major protease classes are known: serine, cysteine, aspartic, threonine, and metallo-proteases. This review focuses on papain-like cysteine protease class. Topics discussed include the biochemistry of human and parasite cysteine proteases and recent developments in inhibitors design, as well as their role in physiology and pathology.