HPV16 transmission between a couple with HPV-related head and neck cancer

Robert Haddad; Christopher Crum; Zigui Chen; Jeffrey Krane; Marshall Posner; Yi Li; Robert Burk

doi:10.1016/j.oraloncology.2007.09.004

HPV16 transmission between a couple with HPV-related head and neck cancer

Robert Haddad, Christopher Crum, Zigui Chen, Jeffrey Krane, Marshall Posner, Yi Li, Robert Burk

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Although squamous cell carcinoma of the head and neck (SCCHN) is closely linked to tobacco and alcohol use, there is an increasing incidence HPV16-related SCCHN arising in the oropharynx. The mechanisms of viral transmission, carcinogenesis and natural history are not well understood. Here, we report a couple-husband and wife diagnosed synchronously with squamous cell carcinoma of the head and neck wherein the tumors were positive for HPV16 by PCR diagnosis. Both viral genomes were genetically identical and closely related to the revised European prototype, HPV16R. An uncommon signal variant nucleotide was identified in both genomes that is not present in the HPV16R. These tumors likely represent transmission between the couple.

Original language	English
Pages (from-to)	812-815
Number of pages	4
Journal	Oral Oncology
Volume	44
Issue number	8
DOIs	https://doi.org/10.1016/j.oraloncology.2007.09.004
State	Published - Aug 2008
Externally published	Yes

Keywords

Head and neck cancer
Human papillomavirus 16

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10.1016/j.oraloncology.2007.09.004

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abstract = "Although squamous cell carcinoma of the head and neck (SCCHN) is closely linked to tobacco and alcohol use, there is an increasing incidence HPV16-related SCCHN arising in the oropharynx. The mechanisms of viral transmission, carcinogenesis and natural history are not well understood. Here, we report a couple-husband and wife diagnosed synchronously with squamous cell carcinoma of the head and neck wherein the tumors were positive for HPV16 by PCR diagnosis. Both viral genomes were genetically identical and closely related to the revised European prototype, HPV16R. An uncommon signal variant nucleotide was identified in both genomes that is not present in the HPV16R. These tumors likely represent transmission between the couple.",

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AU - Crum, Christopher

AU - Chen, Zigui

AU - Krane, Jeffrey

AU - Posner, Marshall

AU - Li, Yi

AU - Burk, Robert

PY - 2008/8

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AB - Although squamous cell carcinoma of the head and neck (SCCHN) is closely linked to tobacco and alcohol use, there is an increasing incidence HPV16-related SCCHN arising in the oropharynx. The mechanisms of viral transmission, carcinogenesis and natural history are not well understood. Here, we report a couple-husband and wife diagnosed synchronously with squamous cell carcinoma of the head and neck wherein the tumors were positive for HPV16 by PCR diagnosis. Both viral genomes were genetically identical and closely related to the revised European prototype, HPV16R. An uncommon signal variant nucleotide was identified in both genomes that is not present in the HPV16R. These tumors likely represent transmission between the couple.

KW - Head and neck cancer

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JF - Oral Oncology

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ER -

HPV16 transmission between a couple with HPV-related head and neck cancer

Abstract

Keywords

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