TY - JOUR
T1 - How to bridle a neutrophil
AU - Rubio-Ponce, Andrea
AU - Hidalgo, Andrés
AU - Ballesteros, Iván
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2021/2
Y1 - 2021/2
N2 - Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.
AB - Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.
UR - https://www.scopus.com/pages/publications/85092162729
U2 - 10.1016/j.coi.2020.08.003
DO - 10.1016/j.coi.2020.08.003
M3 - Review article
C2 - 33038850
AN - SCOPUS:85092162729
SN - 0952-7915
VL - 68
SP - 41
EP - 47
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -