How to bridle a neutrophil

Andrea Rubio-Ponce; Andrés Hidalgo; Iván Ballesteros

doi:10.1016/j.coi.2020.08.003

How to bridle a neutrophil

Andrea Rubio-Ponce
, Andrés Hidalgo
, Iván Ballesteros

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.

Original language	English
Pages (from-to)	41-47
Number of pages	7
Journal	Current Opinion in Immunology
Volume	68
DOIs	https://doi.org/10.1016/j.coi.2020.08.003
State	Published - Feb 2021
Externally published	Yes

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10.1016/j.coi.2020.08.003

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title = "How to bridle a neutrophil",

abstract = "Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.",

author = "Andrea Rubio-Ponce and Andr{\'e}s Hidalgo and Iv{\'a}n Ballesteros",

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doi = "10.1016/j.coi.2020.08.003",

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T1 - How to bridle a neutrophil

AU - Rubio-Ponce, Andrea

AU - Hidalgo, Andrés

AU - Ballesteros, Iván

PY - 2021/2

Y1 - 2021/2

N2 - Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.

AB - Recent high-dimensional technologies have enabled the characterization of heterogeneity in the neutrophil compartment at an unprecedented resolution. In this review, we discuss the emerging notion of heterogeneity within the neutrophil pool, and provide a detailed account of evolving concepts in the field. We place special focus on neutrophil differentiation in the bone marrow and plasticity in tissues, describe the limitations that arise when exploring neutrophil heterogeneity using single-cell analyses, and suggest state-of-the-art alternatives to improve their characterization. Finally, we propose strategies arising from these new concepts that may allow us to bridle neutrophil plasticity towards therapeutic benefit.

UR - https://www.scopus.com/pages/publications/85092162729

U2 - 10.1016/j.coi.2020.08.003

DO - 10.1016/j.coi.2020.08.003

M3 - Review article

C2 - 33038850

AN - SCOPUS:85092162729

SN - 0952-7915

VL - 68

SP - 41

EP - 47

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

ER -

How to bridle a neutrophil

Abstract

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