How Should Methadone Be Started and Titrated in Opioid-Naïve and Opioid-Exposed Patients?

Samantha F. Lau, Mollie A. Biewald

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Methadone is a powerful medication for treating pain in patients with serious illness. Due to unique pharmacological characteristics and action at multiple receptors, it can provide long-acting analgesia to many patients whose pain may be challenging to treat, including those with high opioid requirements or renal failure. These benefits must be weighed against the risks of serious adverse side effects, including arrhythmias, respiratory depression, and the potential for drug interactions. The conversion to methadone from other opioids is not linear and should be approached carefully. With close monitoring and support, methadone can be a safe pain management strategy.

Original languageEnglish
Title of host publicationEvidence-Based Practice of Palliative Medicine, Second Edition
PublisherElsevier
Pages38-45
Number of pages8
ISBN (Electronic)9780323847025
ISBN (Print)9780323847032
DOIs
StatePublished - 1 Jan 2023

Keywords

  • EKG
  • methadone
  • neuropathic pain
  • nociceptive pain
  • opioid
  • pain management

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